Ying JIN Ph.D., Professor Principal Investigator Laboratory of Stem Cell Research Tel: 63852591 Email: yjin@sibs.ac.cn

Education
1983-1988        Ph.D., Pharmacology/Pathophysiology,  Peking Union Medical College (PUMC)
                         and Chinese Academy of Medical Science (CAMS) Beijing, China
1977-1983        M.D., China Medical University, Shenyang, China

Major Academic Appointments
2001.09-Present        Head of Stem Cell Research Lab, Institute of Health Science
                                   Shanghai Institutes for Biological Sciences, CAS / Shanghai JiaoTong University of Medicine, China
1999.09-Present        Shanghai JiaoTong University of Medicine, China
1994.09-1998.01        Research fellow, Molecular Immunology Center, Department of Microbiology,
                                   University of Texas Southwestern Medical Center, Dallas, Texas
1988.10-1994.09        Postdoctoral fellow, Department of Pharmacology, The University of North Texas Health Science Center,
                                   Fort Worth, Texas

Honors, Certificates, and Academic Society
1988-1994        Achievement award in ocular Pharmacology, University of North Texas, Health Science Center, Texas
1995.6.1           CA09082-20, NIH cancer immunology training grant
The association for research in vision and ophthalmology (ARVO) travel fellowship for the 1993 annual meeting in Sarasota, Florida.
ISSCR members 2003, 2004, 2005

Major Research Achievement
        1. Establish platform to study protein-protein and protein-DNA interaction in ES cells and identify new proteins associated with
transcription factor Oct-4 and new target genes of Oct-4. By affinity purification, several novel Oct-4-associated proteins were identified.
Ubiquitin E3 ligase, Wwp2, was found to specifically interact with Oct-4 and regulates transcriptional activity of Oct-4. It was firstly
demonstrated and Oct-4 can be ubiquitinated and Wwp2 is its E3 ligase. The further investigation about how this protein regulates activity
of Oct-4 and its function in ES cell differentiation is currently under way.
        2. Establish mouse and human ES cell lines. Human embryonic stem cell line has been derived and fully characterized. In addition,
mouse ES cells both from normally fertilized embyos and parthenogenetically activated embryos were derived and characterized. These
cell lines provide in vitro models to study molecular mechanisms to regulate proliferation and differentiation in ES cells. Moreover, the
parthenogenetic ES cells will help to study genomic imprinting and epigenetic regulation.

Recent Publications

1. Li L, Sun L, Gao F, Jiang J, Yang Y, Li C, Gu J, Wei Z, Yang A, Lu R, Ma Y, Tang F, Won Kwon S, Zhao Y, Li J, Jin Y. Stk40 links the pluripotency factor Oct4 to the Erk/MAPK pathway and controls extraembryonic endoderm differentiation. Proc Natl Acad Sci U S A. 2010 Jan 4. [Epub ahead of print]

2. Liao B, Jin Y. Wwp2 mediates Oct4 ubiquitination and its own auto-ubiquitination in a dosage-dependent manner. Cell Res. 2009 Dec 8. [Epub ahead of print]

3. Chunliang Li, Hongyao Yu, Yu Ma, Hua Jiang, Jing Jiang, Junjie Gu, Guilai Shi, Ying Yang, Jinsong Li, Ying Jin. Germline-competent mouse-induced pluripotent stem cell lines generated on human fibroblasts without exogenous leukemia inhibitory factor. PloS ONE. 2009 Aug;4(8):e6724.

4. Li H, Wang B, Yang A, Lu R, Wang W, Zhou Y, Shi G, Kwon SW, Zhao Y, Jin Y. Ly-1 antibody reactive clone is an important nucleolar protein for control of self-renewal and differentiation in embryonic stem cells. Stem Cells. 2009 Jun;27(6):1244-54.

5. Li C, Zhou J, Shi G, Ma Y, Yang Y, Gu J, Yu H, Jin S, Wei Z, Chen F, Jin Y. Pluripotency can be rapidly and efficiently induced in human amniotic fluid-derived cells. Hum Mol Genet. 2009 Nov 15;18(22):4340-9.

6. Zhong X, Jin Y. Critical roles of coactivator p300 in mouse embryonic stem cell differentiation and nanog expression. J Biol Chem. 2009 Apr 3;284(14):9168-75.

7. Gao F, Kwon SW, Zhao Y, Jin Y. PARP1 poly(ADP-ribosyl)ates Sox2 to control Sox2 protein levels and FGF4 expression during embryonic stem cell differentiation. J Biol Chem. 2009 Aug 14; 284(33):22263-73.

8. Li C, Yang Y, Gu J, Ma Y, Jin Y. Derivation and transcriptional profiling analysis of pluripotent stem cell lines from rat blastocysts. Cell Res. 2009 Feb; 19(2):173-86.

9. Xu H, Wang W, Li C, Yu H, Yang A, Wang B, Jin Y. WWP2 promotes degradation of transcription factor OCT4 in human embryonic stem cells. Cell Res. 2009 Jun; 19(6):796.

>>> All Publications