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 The Key Laboratory of Stem Cell Biology was established in 2001 under the support of Shanghai Institute for Biological Sciences, Chinese Academy of Sciences. Researcher Ying Jin (Director of the Shanghai Stem Cell Institute ) took as the director of the Lab, while the academician Gang Pei took as the director of the scientific committee. In recent years, Key Laboratory has condensed the further research direction: They oriented on the important issues of clinical cell therapy, carried out the establishment of stem cell lines; stem cells pluripotent maintenance and molecular mechanism regulation; research on immune regulation ; and directed differentiation into nerve / heart / bone cells, With help of clinical research platform and team, they will stick to solve important scientific and clinical issues in the field of stem cell research.
Academic Committee:
Chairman: Gang PEI, Academician, Tong Ji University
Vice-Chairman: Lin LI, SIBS
Member: Guoqiang CHEN, Yan CHEN, Jianwu DAI, Ying JIN, Naihe JING, Weijun MA, Duanqing PEI, Xuetao PEI, Yufang SHI, Huangtian YANG, Qi ZHOU, Xueliang ZHU
Main Research Focuses:
 Establishment of embryonic stem (ES) and induced pluripotent stem (iPS) cell lines and investigation of molecular mechanisms controlling pluripotency and self-renewal;
Differentiation of ES and iPS cells into cardiomyocytes, neural and hematopoietic lineages as well as dissection of underlying mechanisms at a molecular level; Investigation of signal transduction pathways of differentiation, apoptosis and self-renewal in hematopoietic stem cells using zebrafish as a model system; Isolation, purification and identification of adult stem cells; Discovery of new cell surface markers of adult stem cells; Application of adult stem cells in disease treatment; Immuno-associated studies in stem cell transplantation, particularly for the immuno-rejection problem; Isolation and identification of tumor stem cells to provide new drug targets for tumor treatment. Elucidation of molecular networks regulating tumor development to find new approaches for early diagnosis of tumors.
Research groups:
KLSCB has 14 regular member research groups, 26 guest seat research groups, and 6 platform. Altogether, KLSCB has now 339 members, including 28 scientists and 125 staff and 203 graduate students. The 14 regular member research groups are headed by the following principal investigators:
Yufang SHI, Director, IHS
Ying JIN, IHS
Huangtian YANG, Vice Director, IHS
Tingxi LIU, Director Assistant, IHS
Yanyun ZHANG, Vice Director, IHS
Kerong Dai, IHS
Xiangyin KONG, Director Assistant, IHS
Baoxue GE, IHS
Guohong HU, IHS
Shengdi CHEN, IHS
Guang NING, IHS
Weidong LE, IHS
Pingjing GAO, IHS
Yue QIN, IHS
KLSCB focuses its research on stem cell translational research. Some groups continue their efforts in explore the basic scientific truth like the molecular mechanism for the maintenance and regulation of the pluropotency of the embryonic stem cells, high quality stem cell lines establishment, as well as the proliferation, differentiation and apoptosis of stem cells. Others are targeting their research at the solution of the clinical challenge for stem cell application, including the differentiation of stem cells into different types of cell, immunological regulations when stem cells as a cell therapy, and so on. The third group is working on the establishment of core technology platform and training base for stem cell research. Regardless the efforts in different groups, the overall work are guided to the solution of some key problems in stem cell application while the basic mechanism is explored.
 Since the reorganization of the KLSCB, significant progress has been made. By the end of June 2006, the member groups of KLSCB already published several papers, which are among the top stem cell research papers generated in China. KLSCB has been also actively participating the activities in the international and domestic stem cell research communities. Following the Eastern China Science and Technology Forum on Stem Cell (Stem Cell Research: From Bench to Bedside) organized by the KLSCB member groups, the professors participated various international conference, symposium, visiting colleagues around the world and deliver lectures in the research institutions around the world. Recently, Dr. Ying Jin has been elected as the annual meeting program committee member of International Society for Stem Cell Research. A China-ISSCR Stem Cell Conference in Shanghai in 2007 is under discussion and actively preparation.
In order to promote stem cell research in Shanghai and China and internationally, KLSCB is working to serve more scientists in their research as a 'public' stem cell research platform. We can currently provide the following service and technology support while continuing efforts to increase our capacity:
• Provide human embryonic stem cells (from SHhES1, a hES cell line established in Dr. Jin's lab);
• Provide mouse embryonic stem cells (from rES cell lines established in Dr. Jin's lab);
• Provide parthenogenetic mouse embryonic stem cells (established in Dr. Jin's lab);
• Provide mouse embryonic fibroblast (MEF) cells;
• Provide training opportunities at KLSCB in stem cell culture and feeder preparation, etc.
All materials can be provided upon arrangement with MTA.
Contact:
Xiaohui Ren
225 South Chongqing Road, Room 208, Building 1
Shanghai, 200025, China
Tel: 86-21-63858255
Fax: 86-21-63852655
E-mail: renxiaohui710409@sina.com; xhren@sibs.ac.cn
Current publications by KLSCB members:
2011
Cao W, Yang Y, Wang Z, Liu A, Fang L, Wu F, Hong J, Shi Y, Leung S, Dong C, Zhang JZ. Leukemia Inhibitory Factor Inhibits T Helper 17 Cell Differentiation and Confers Treatment Effects of Neural Progenitor Cell Therapy in Autoimmune Disease. Immunity. 2011 Aug 9. [Epub ahead of print] Zhou T, Wang L, Zhu KY, Dong M, Xu PF, Chen Y, Chen SJ, Chen Z, Deng M, Liu TX*. Dominant-negative C/ebp汐 and polycomb group protein Bmi1 extends short-lived hematopoietic stem/progenitor cells lifespan and induces lethal dyserythropoiesis. Blood. 2011 Aug 9. [Epub ahead of print] Xiaobing Luo∫, Wanling Yang, Dong-Qing Ye, Huijuan Cui∫, Yan Zhang, Nattiya Hirankarn, Xiaoxia Qian, Yuanjia Tang, Yu Lung Lau, Niek de Vries, Paul Peter Tak, Betty P. Tsao, Nan Shen*. A Functional Variant in MicroRNA-146a Promoter Modulates Its Expression and Confers Disease Risk for Systemic Lupus Erythematosus. PLoS Genetics. 2011;7(6): e10021 Li-Ling Wang∫, Xiao-Ling Pan, Ying Wang, Hui-Dong Tang,Yu-Lei Deng, Ru-Jing Ren, Wei Xu, Jian-Fang Ma, Gang Wang, Sheng-Di Chen∫*. A Single Nucleotide Polymorphism in LRP2 Is Associated with Susceptibility to Alzheimer's Disease in the Chinese Population. Clinica Chemica Acta. 2011 Jan 30;412(3-4):268-70. Yu Shi∫, Huiwu Li, Xiaoling Zhang∫, Yujie Fu∫, Yan Huang∫, Pauline Po Yee Lui, Tingting Tang, Kerong Dai*∫. Continuous cyclic mechanical tension inhibited Runx2 expression in mesenchymal stem cells through RhoA-ERK1/2 pathway. Journal of Cellular Physiology. 2010 Dec 6. [Epub ahead of print] Mao C∫, Wang S, Xiao Y∫, Xu J∫, Jiang Q, Jin M∫, Jiang X, Guo H, Ning G*, Zhang Y*∫. Impairment of Regulatory Capacity of CD4+CD25+ Regulatory T Cells Mediated by Dendritic Cell Polarization and Hyperthyroidism in Patients with Graves'Disease. J Immunol. Prepublished online 2011 Mar 11. Yang Liu∫, Haiming Xu, Suchao Chen, Xianfeng Chen∫, Zhenguo Zhang∫, Zhihong Zhu, Xueying Qin, Landian Hu∫, Jun Zhu, Guo-Ping Zhao, Xiangyin Kong∫*. Genome-Wide Interaction-Based Association Analysis Identified Multiple New Susceptibility Loci for Common Diseases. PLoS Genet 2011 Mar 17;7(3): e100133 Cao N∫, Liao J, Liu Z∫, Zhu W∫, Wang J∫, Liu L, Yu L, Xu P, Cui C, Xiao L, Yang H*∫. In vitro differentiation of rat embryonic stem cells into functional cardiomyocytes. Cell Research. 2011 Mar 22; 1-16. Lu R∫, Yang A∫, Jin Y*∫. Dual Functions of T-Box 3 (Tbx3) in the Control of Self-renewal and Extraembryonic Endoderm Differentiation in Mouse Embryonic Stem Cells. Journal of Biological Chemistry. 2011 Mar 11; 286(10):8425-36. Xu W∫, Yu Z∫, Xie Y∫, Huang G, Shu X, Zhu Y∫, Zhou Z, Yang H*∫. Therapeutic effect of intermittent hypobaric hypoxia on myocardial infarction in rats. Basic Res Cardiol. 2011 Feb 7. Li X∫, Zhu L∫, Yang A∫, Lin J, Tang F∫, Jin S∫, Wei Z∫, Li J, Jin Y*∫. Calcineurin-NFAT Signaling Critically Regulates Early Lineage Specification in Mouse Embryonic Stem Cells and Embryos. Cell Stem Cell. 2011 Jan 7; 8(1):46-58. Zou J, Li WQ, Li Q, Li XQ, Zhang JT, Liu GQ, Chen J, Qiu XX, Tian FJ, Wang ZZ, Zhu N, Qin YW, Shen B, Liu TX*, Jing Q*∫ (2011) Two Functional MicroRNA-126s Repress a Novel Target Gene P21-Activated Kinase1 to Regulate Vascular Integrity in Zebrafish. Circ Res. Jan 21;108(2):201-9.
2010
Qing-Yun Li∫, Hong-Mei Wang, Zhi-Quan Wang, Jian-Fang Ma, Jian-Qing Ding, Sheng-Di Chen∫*. Salidroside attenuates hypoxia-induced abnormal processing of 汕-amyloid precursor protein by decreasing BACE1 expression in SH-SY5Y cells. Neurosci Lett. 2010 Sep 13;481(3):154-8. Xianfeng Chen, Xinlei Li, Ping Wang, Yang Liu, Zhenguo Zhang, Guoping Zhao, Haiming Xu, Jun Zhu, Xueying Qin, Suchao Chen, Landian Hu, Xiangyin Kong*∫ (2010) Novel Association Strategy with Copy Number Variation for Identifying New Risk Loci of Human Diseases. PloS ONE. 2010; 5(8):e12185. Xu H∫, Wang P, You J, Zheng Y, Fu Y, Tang Q, Zhou L, Wei Z, Lin B, Shu Y, Zhu Y, Hu L, Kong X*∫(2010) Screening of Kozak-motif-located SNPs and analysis of their association with human diseases. Biochem Biophys Res Commun. 392:89-94. Xiaohui Ren∫, Jingya Zhang, Xiaowen Gong (2010) In vitro differentiation of murine embryonic stem cells toward renal lineage following conditioned medium from ureteric bud cells. Acta Biochim Biophys Sin. 42: 464-471. ZhenguoZhang, LiZhou, LandianHu, YufeiZhu, HengXu, YangLiu, XianfenChen, XianfuYi, Kong X*∫ and Laurence D Hurst (2010) Nonsense-mediated decaytargets have multiple sequence-related features that can inhibit translation. Molecular Systems Biology; Article number KK; doi:10.1038/msb.101. Zhongping Xu, Yufang Zheng, Yufei Zhu, Landian Hu, Kong X*∫ (2010) Evidence for OTUD-6B participates in B lymphocytes cell cycle after cytokine stimulation. PLoS One. 6(1):e14514. Xiao Y∫, Xu J, Wang S, Mao C, Jin M, Ning G, Xu J, Zhang Y*∫ (2010) Genetic ablation of steroid receptor coactivator-3 promotes PPAR-b-mediated alternative activation of microglia in experimental autoimmune encephalomyelitis. Glia. 58:932每942. Chunhui Zhang, Li Hao, Liang Wang, Yichuan Xiao, Hailiang Ge, Yunbao Luo, Yi Zhang and Yanyun Zhang∫* (2010) Elevated IGFIR expression regulating VEGF and VEGF-C predicts lymph node metastasis in human colorectal cancer. BMC Cancer. 10:184[**]. Fang Zhao∫, Yi Zhang, Hao Wang, Min Jin, Shan He, Yufang Shi, Yajun Guo and Yanyun Zhang*∫ (2010) Blockade of osteopontin reduces alloreactive CD8+ T cell-mediated graft-versus-host disease. Blood. 30,doi:10.1182/blood-2010-04-281659. Shu Zhu∫, Wen Pan∫, Peiqing Shi∫, Hanchao Gao∫, Fang Zhao∫, Xinyang Song∫, Yan Liu∫, Lihua Zhao∫, Xiaoxia Li, Yufang Shi∫, and Youcun Qian∫* (2010) Modulation of experimental autoimmune encephalomyelitis through TRAF3-mediated suppression of interleukin 17 receptor signaling. J. Exp. Med. 207(12):2647-2662. Youcun Qian∫*, Zizhen Kang, Caini Liu and Xiaoxia Li (2010) IL-17 signaling in host defense and inflammatory diseases. Cell Mol Immunol. 7, 328-333. Zhang X∫, Li L∫, Wang Q, Chen S, Yang D∫, Wang Y, Le W∫* (2010) Pathological role of rapamycin treatment in motor neuron degeneration in SOD1G93A mouse model of amyotrophic lateral sclerosis correlates with altered autophagy. Autophagy. In press. Song XW, Li Q, Lin L, Li DF, Wang GK, Ren AJ, Qin YW, Yuan WJ, Jing Q*∫ (2010) MicroRNAs are dynamically regulated in hypertrophic hearts, and miR-199a is essential for the maintenance of cell size in cardiomyocytes. J Cell Physiol. 225:437-443 [Epub ahead of print] PubMed PMID: 20458739. Shao Q, Shen LH, Hu LH, Pu J, Qi MY, Li WQ, Tian FJ, Jing Q*∫, He B (2010) Nuclear receptor Nur77 suppresses inflammatory response dependent on COX-2 in macrophages induced by oxLDL. J Mol Cell Cardiol. 49(2):304-311. Cheng-Chao Ruan, Ding-Liang Zhu, Jing Chen, Shu-Jie Guo, Xiao-Dong Li, Ping-Jin Gao*∫ (2010) Perivascular Adipose Tissue每Derived Complement 3 Is Required for Adventitial Fibroblast Functions and Adventitial Remodeling in Deoxycorticosterone Acetate每Salt Hypertensive Rats. Arteriosclerosis, Thrombosis, and Vascular Biology. 30:2568. Xiaohui Ren∫, Jingya Zhang, Xiaowen Gong (2010) In vitro differentiation of murine embryonic stem cells toward renal lineage following conditioned medium from ureteric bud cells. Acta Biochim Biophys Sin. 42: 464-471. Hai Fang∫, Ying Yang, Chunliang Li, Shijun Fu, Zuqing Yang, Gang Jin, Kankan Wang, Ji Zhang*∫, Ying Jin*∫. Transcriptome analysis of early organogenesis in human embryos. Developmental Cell. 2010;19:174-184. Guo-Kun Wang∫, Jia-Qi Zhu, Jun-Tao Zhang, Qing Li, Yue Li, Jia He, Yong-Wen Qin, and Qing Jing*∫. Circulating microRNA: a novel potential biomarker for early diagnosis of acute myocardial infarction in humans. European Heart Journal. 2010;31:659-666. Qing Li∫, Xiao-Wei Song, Jun Zou, Guo-Kun Wang, Elena Kremneva, Xiang-Qi Li, Ni Zhu, Tao Sun, Pekka Lappalainen, Wen-Jun Yuan, Yong-Wen Qin and Qing Jing*∫. Attenuation of microRNA-1 derepresses the cytoskeleton regulatory protein twinfilin-1 to provoke cardiac hypertrophy. Journal of Cell Science. 2010;123 (14):2442-2452. Li L∫, Sun L, Gao F, Jiang J, Yang Y, Li C, Gu J, Wei Z, Yang A, Lu R, Ma Y, Tang F, Won Kwon S, Zhao Y, Li J, Jin Y*∫. Stk40 links the pluripotency factor Oct4 to the Erk/MAPK pathway and controls extraembryonic endoderm differentiation. Proc Natl Acad Sci USA. 2010;107(4): 1402-1407. Li C∫, Yang Y, Lu X, Sun Y, Gu J, Feng Y, Jin Y*. Efficient derivation of Chinese human embryonic stem cell lines from frozen embryos. In Vitro Cell Dev Biol Anim. - Animal 2010; 46:186-191. Liang J∫, Wang Y, Tang Y, Cao N, Wang J, Yang H*∫. Type 3 inositol 1,4,5-trisphosphate receptor negatively regulates apoptosis during mouse embryonic stem cell differentiation. Cell Death Differ. 2010;17, 1141-1154. Shi Y*∫, Hu G, Su J, Li W, Chen Q, Shou P, Xu C, Chen X, Huang Y, Zhu Z, Huang X, Han X, Xie N, Ren G. Mesenchymal stem cells: a new strategy for immunosuppression and tissue repair. Cell Res. 2010;20: 510-518. Zhao X, Ren G, Liang L, Zheng B, Tischfield JA, Shi Y*∫, Shao CS. Brief report: IFN-g induces expansion of Lin-Sca-1+C-Kit+ Cells. Stem Cells. 2010;28: 122-126. Ren G, Zhao X, Zhang L, Zhang J, L＊Huillier A, Ling W, Roberts AI, Le A, Shi S, Shao C, Shi Y*∫. Inflammatory Cytokine-Induced Intercellular Adhesion Molecule-1 and Vascular Cell Adhesion Molecule-1 in Mesenchymal Stem Cells Are Critical for Immunosuppression. J Immunol. 2010;184:2321-2328. Arriola A., Kiel, M. E., Shi Y*∫, McKinnon, R.D. Adjunctive MSCs enhance myelin formation by xenogenic oligodendrocyte precursors transplanted in the retina. Cell Res. 2010;20(6):728-31. Fu C∫, Zhu K, Mi J, Liu Y, Murray S, Fu Y, Ren C, Dong Z, Liu Y, Dong M, Jin Y, Chen Y, Deng M, Zhang W, Chen B, Breslin P, Chen S, Chen Z, Becker M, Zhu J, Zhang J, Liu T*∫. An evolutionarily conserved PTEN-C/EBP{alpha}-CTNNA1 axis controls myeloid development and transformation. Blood. 2010 Jun 10;115(23):4715-24. Xu P∫, Zhu K, Jin Y, Chen Y, Sun X, Deng M, Chen S, Chen Z∫, Liu T*∫. Setdb2 restricts dorsal organizer territory and regulates left-right asymmetry through suppressing fgf8 activity. Proc Natl Acad Sci USA. 2010;107(6):2521-2526. Xu H∫, Wang P, Fu Y, Zheng Y, Tang Q, Si L, You J, Zhang Z, Zhu Y, Zhou L, Wei Z, Lin B, Hu L, Kong X*∫. Length of the ORF, position of the first AUG and the Kozak motif are important factors in potential al-coding transcripts. Cell Res. 2010;20:445-457. Zhou L∫, Zhang Z, Zheng Y, Zhu Y, Wei Z, Xu H, Tang Q, Kong X, Hu L*∫. SKAP2, a novel target of HSF4b, associates with NCK2/F-actin at membrane ruffles and regulates actin reorganization in lens cell. J Cell Mol Med. 2010 Mar 9 [Epub ahead of print] Xu H∫, Wang P, You J, Zheng Y, Fu Y, Tang Q, Zhou L, Wei Z, Lin B, Shu Y, Zhu Y, Hu L, Kong X*∫. Screening of Kozak-motif-located SNPs and analysis of their association with human diseases. Biochem Biophys Res Commun. 2010;392:89-94. Xiao Y∫, Xu J, Wang S, Mao C, Jin M, Ning G, Xu J, Zhang Y*∫. Genetic ablation of steroid receptor coactivator-3 promotes PPAR-b-mediated alternative activation of microglia in experimental autoimmune encephalomyelitis. Glia. 2010;58:932每942. Cao Q∫, Jin Y, Jin M, He S, Gu Q, He S, Qiu Y, Ge H, Yoneyama H, Zhang Y*∫. Therapeutic effect of MIP-1alpha-recruited dendritic cells on preestablished solid and metastatic tumors. Cancer Lett. 2010 Sep 1;295(1):17-26. Fan X∫ , Luo G, Yang D, Ming Ming, Hongmei Liu, Pu Pu, Weidong Le*∫. Critical role of lysosome and its associated protein cathepsin D in manganese-induced toxicity in cultured midbrain astrocyte. Neurochem Int. 2010 Jan;56(2):291-300. Xiao Y, Xu J, Mao C, Jin M, Wu Q, Zou J, Gu Q, Zhang Y, Zhang Y*∫. 18汕-glycyrrhetinic acid ameliorated Propionibacterium acnes-induced acute liver injury through inhibition of MIP-1汐. J Biol Chem. 2010 Jan 8;285(2):1128-37.
2009
Chunliang Li∫, Ying Yang, Junjie Gu, Yu Ma, Ying Jin*∫. Derivation and transcriptional profiling analysis of pluripotent stem cell lines from rat blastocysts. Cell Res. 2009;19(2):173-186. Li H∫, Wang B, Yang A, Lu R, Wang W, Zhou Y, Shi G, Kwon SW, Zhao Y, Jin Y*∫. Ly-1 Antibody Reactive Clone Is an Important Nucleolar Protein for Control of Self-Renewal and Differentiation in Embryonic Stem Cells. Stem cells. 2009;27:1244-1254. Yan Xu∫, Dechun Feng, Ying Wang, Qingqiong Luo and Lingyun Xu*∫. STAT3 Mediates Protection From Liver Inflammation After Partial Hepatectomy. Cell Physiol Biochem. 2009;23:379-386. Xiaomin Zhong∫ and Ying Jin*∫. Critical roles of coactivator p300 in mouse embryonic stem cell differentiation and Nanog expression. J Biol Chem. 2009;284(14):9168-9175. Ting-Ting Dua∫, Yan-Fang Fu, Mei Dong, Lei Wang, Hong-Bo Fan, Yi Chen, Yi Jin, Sai-Juan Chen, Zhu Chen , Min Deng, Qiu-Hua Huang, Ting Xi Liu*∫. Experimental validation and complexity of miRNA每mRNA target interaction during zebrafish primitive erythropoiesis. BBRC. 2009;381(4):688-693. Xu, H∫., Wang, W., Li, C., Yu, H., Yang, A., Wang, B., Jin, Y*∫. WWP2 promotes degradation of transcription factor OCT4 in human embryonic stem cells. Cell Res. 2009;19:561-573. Yu Z∫, Wang ZH, Yang HT*∫. Calcium/calmodulin-dependent protein kinase II mediates cardioprotection of intermittent hypoxia against ischemic-reperfusion-induced cardiac dysfunction. Am J Physiol Heart Circ Physiol. 2009;297(2):H735-742. Run-Zhe Shu∫, Feng Zhang, Fang Wang, De-Chun Feng, Xi-Hua Li, Wei-Hua Ren, Xiao-Lin Wu, Xue Yang, Xiao-Dong Liao, Lei Huang and Zhu-Gang Wang*∫. Adiponectin deficiency impairs liver regeneration through attenuating STAT3 phosphorylation in mice. Laboratory Investigation. 2009;1-10. Mei Dong, Yan-Fang Fu, Ting-Ting Du, Chang-Bin Jing, Chun-Tang Fu, Yi Chen, Yi Jin, Min Deng, Ting Xi Liu*∫. Heritable and Lineage-Specific Gene Knockdown in Zebrafish Embryo. PLoS One. 2009; 4(7):e6125. Shanye Yin∫, Ping Wang, Wenjun Deng, Hancheng Zheng, Landian Hu, Laurence D Hurst, Xiangyin Kong*∫. Dosage compensation on the active X chromosome minimizes transcriptional noise of X-linked genes in mammals. Genome Biology. 2009;10:R74. Guo A∫, Yang HT*∫. Ca2+ removal mechanisms in mouse embryonic stem cell-derived cardiomyocytes. Am J Physiol Cell Physiol. 2009;297(3): C732-C741. Chunliang Li∫, Junmei Zhou, Guilai Shi, Yu Ma1, Ying Yang, Junjie Gu, Hongyao Yu, Shibo Jin, Zhe Wei, Fang Chen, Ying Jin*∫. Pluripotency can be rapidly and efficiently induced in human amniotic fluid-derived cells. Hum Mol Genet. 2009;18(22):4340-4349. Furong Gao∫, Sung Won Kwon, Yingming Zhao, and Ying Jin*∫. PARP1 poly(ADP-ribosyl)ates Sox2 to control Sox2 protein levels and FGF4 expression during embryonic stem cell differentiation. J Biol Chem. 2009;284(33):22263-73. Ling Kong∫, Lei Sun, Hongxin Zhang, Qin Liu, Ye Liu, Linhua Qin, Guojun Shi, Jun-Hao Hu, Ajing Xu, Yue-Ping Sun, Dangsheng Li, Yu-Fang Shi, Jing-Wu Zang, Jiang Zhu, Zhu Chen, Zhu-Gang Wang*, Bao-Xue Ge*∫. An essential role for RIG-I in toll-like receptor-stimulated phagocytosis. Cell Host Microbe. 2009;6(2):150-61. Chunliang Li∫, Hongyao Yu, Yu Ma, Guilai Shi, Jing Jiang, Junjie Gu, Ying Yang, Shibo Jin, Zhe Wei, Hua Jiang, Jinsong Li, Ying Jin*∫. Germline-competent mouse-induced pluripotent stem cell lines generated on human fibroblasts without exogenous leukemia inhibitory factor. PLoS One. 2009;21;4(8): e6724. Run-Zhe Shu∫, Feng Zhang, Xue-Song Liu, Chun-Liang Li, Long Wang, Yi-Lin Tai, Xiao-Lin Wu, Xue Yang, Xiao-Dong Liao, Ying Jin, Ming-Min Gu, Lei Huang, Xiao-Fen Pang, Zhu-Gang Wang*∫. Target Deletion of the Cytoskeleton-Associated Protein Palladin Does Not Impair Neurite Outgrowth in Mice. PLoS One. 2009;4(9): e6916. Haijun Tong∫, Qin Shi, Julio C. Fernandes, Li Liu, Kerong Dai and Xiaoling Zhang*∫. Progress and Prospects of Chitosan and Its Derivatives as Non-Viral Gene Vectors in Gene Therapy. Current Gene Therapy. 2009;9:495-502. Jinwen Tu∫, Huajie Wang, Huiwu Li, Kerong Dai, Jinye Wang, Xiaoling Zhang*∫. The in vivo bone formation by mesenchymal stem cells in zein scaffolds. Biomaterials. 2009;30(26):4369-4376. Yan Huang∫, Xiaogang Jin, Xiaoling Zhang, Hongli Sun, Jinwen Tu, Tingting Tang, Jiang Chang, Kerong Dai*∫. In vitro and in vivo evaluation of akermanite bioceramics for bone regeneration. Biomaterials. 2009;30(28):5041-5048. Youheng Wei∫, Qianghai Xiao, Ting Zhang, Zongchun Mou, Jia You and Wei-Jun Ma*∫. Differential regulation of mRNA stability controls the transient expression of genes encoding Drosophila antimicrobial peptide with distinct immune response characteristics. Nucleic Acids Research. 2009;37(19):6550-6561. Zhenguo Zhang∫, Li Zhou, Ping Wang, Yang Liu, Xianfeng Chen, Landian Hu and Xiangyin Kong*∫. Divergence of exonic splicing elements after gene duplication and the impact on gene structures. Genome Biology. 2009;10(11):R120. Qian Y∫, Shi Y*∫. Natural killer cells go inside: entosis versus cannibalism. Cell Res. 2009; 19:1320-1321.
2008
Hui-Mei Yu∫, Jing Wen, Rong Wang, Wan-Hua Shen, Shumin Duan and Huang-Tian Yang*∫. Critical role of type 2 ryanodine receptor in mediating activity-dependent neurogenesis from embryonic stem cells. Cell Calcium. 2008; 43(5):417-31. Wang R∫, Liang J, Jiang H, Qin LJ, Yang HT*∫. Promoter-dependent EGFP expression during embryonic stem cell propagation and differentiation. Stem Cells Dev. 2008; 17:279-89. Chengyong Shen∫, Yongfeng Chen, Huaqing Liu, Kejing Zhang, Ting Zhang, Anning Lin, and Naihe Jing*∫. Hydrogen peroxide promotes Abeta production through JNK-dependent activation of gamma-secretase. J Biol Chem. 2008; 283:17721-30. Xin Lou∫, Shuangwei Li, Jinhu Wang, Xiaoyan Ding*∫. Activin/nodal signaling modulates XPAPC expression during Xenopus gastrulation. Dev Dyn. 2008; 237:683-91. Li S∫, Lou X, Wang J, Liu B, Ma L, Su Z, Ding X*∫. Retinoid signaling can repress blastula Wnt signaling and impair dorsal development in Xenopus embryo. Differentiation. 2008; 76:897-907. Fang H∫, Wang K, and Zhang J*∫. Transcriptome and proteome analyses of drug interactions with natural products. Curr Drug Metab. 2008; 9:1038-48. He S, Cao Q, Qiu Y, Mi J, Zhang J Z, Matsushima K, Jin M, Ge H, Emerson S, Zhang Y and Zhang Y*. A new approach of blocking alloreactive T cell-mediated GVHD by in vivo administration of anti-CXCR3 neutralizing antibody. Journal of Immunology. 2008;181:7581.
2007
Yuan Y∫, Gao X, Guo N, Zhang H, Xie Z, Jin M, Li B, Yu L, Jing N*∫. rSac3, a novel Sac domain phosphoinositide phosphatase, promotes neurite outgrowth in PC12 cells. Cell Res. 2007; 17:919-32. Xu P∫ and Ding X*∫. Characterization and expression of mouse Cdc50c during spermatogenesis. Acta Biochim Biophys Sin. 2007; 39:739-44. Xia C∫, Wang C, Zhang K, Qian C, Jing N*∫. Induction of a high population of neural stem cells with anterior neuroectoderm characters from epiblast-like P19 embryonic carcinoma cells. Differentiation. 2007; 75:912-27. Li H∫, Zhang Z, Wang B, Zhang J, Zhao Y, Jin Y*∫. Wwp2-mediated ubiquitination of the RNA polymerase II large subunit in mouse embryonic pluripotent stem cells. Mol Cell Biol. 2007; 27:5296-305. Jiang H∫, Sun B, Wang W, Zhang Z, Gao F, Shi G, Cui B, Kong X, He Z, Ding X, Kuang Y, Fei J, Sun YJ, Feng Y, Jin Y*∫. Activation of paternally expressed imprinted genes in newly derived germline-competent mouse parthenogenetic embryonic stem cell lines. Cell Res. 2007; 17:792-803. Bai G∫, Sheng N, Xie Z, Bian W, Yokota Y, Benezra R, Kageyama R, Guillemot F, Jing N*∫. Id sustains Hes1 expression to inhibit precocious neurogenesis by releasing negative autoregulation of Hes1. Dev Cell. 2007; 13:283-97. Zhang Z∫, Liao B, Xu M, Jin Y*∫. Post-translational modification of POU domain transcription factor Oct-4 by SUMO-1. FASEB J. 2007 Oct;21(12):3042-51. Wang J∫, Li S, Chen Y, Ding X*∫. Wnt/beta-catenin signaling controls Mespo expression to regulate segmentation during Xenopus somitogenesis. Dev Biol. 2007 Apr 15;304(2):836-47.
2006
Wang C∫, Xia C, Bian W, Liu L, Lin W, Chen YG, Ang SL, Jing N*∫. Cell aggregation-induced FGF8 elevation is essential for P19 cell neural differentiation. Mol Biol Cell. 2006 Jul;17(7):3075-84. Wang C∫, Bian W, Xia C, Zhang T, Guillemot F, Jing N*∫. Visualization of bHLH transcription factor interactions in living mammalian cell nuclei and developing chicken neural tube by FRET. Cell Res. 2006 Jun;16(6):585-98. Wang BB∫, Lu R, Wang WC, Jin Y*∫. Inducible and reversible suppression of Npm1 gene expression using stably integrated small interfering RNA vector in mouse embryonic stem cells. Biochem Biophys Res Commun. 2006 Sep 8;347(4):1129-37. Fu JD∫, Yu HM, Wang R, Liang J, Yang HT*∫. Developmental regulation of intracellular calcium transients during cardiomyocytedifferentiation of mouse embryonic stem cells. Acta Pharmacol Sin. 2006 Jul;27(7):901-10. Fu J D∫ and Yang H T*∫. Developmental regulation of intracellular calcium homeostasis in early cardiac myocytes. Sheng Li Xue Bao. 2006; 58:95-103. Fu JD∫, Li J, Tweedie D, Yu HM, Chen L, Wang R, Riordon DR, Brugh SA, Wang SQ, Boheler KR, Yang HT*∫. Crucial role of the sarcoplasmic reticulum in the developmental regulation of Ca2+ transients and contraction in cardiomyocytes derived from embryonic stem cells. FASEB J. 2006 Jan;20(1):181-3. Wu D Y∫ and Yao Z*∫. Functional analysis of two Sp1/Sp3 binding sites in murine Nanog gene promoter. Cell Res. 2006; 16:319-22. |
