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Principal Investigators

Faculty and Staff

Principal Investigators
Ph.D., Professor, Principal Investigator
Laboratory of development and diseases

Research Interests or Current Research Focus
1. Signal regulation and reprogramming mechanisms of cardiac progenitors;
2. Molecular mechanisms of normal haematopoietic and tumor stem cell malignant transformation, including epigenetics and key node genes analysis

Major Research Achievement
The four-chambered mammalian heart develops from two fields of cardiac progenitor cells distinguished by their spatiotemporal patterns of differentiation and contributions to the definitive heart. The first heart field differentiates earlier in lateral plate mesoderm, generates the linear heart tube and ultimately gives rise to the left ventricle. The second heart field (SHF) differentiates later in pharyngeal mesoderm, elongates the heart tube, and gives rise to the outflow tract and much of the right ventricle. Because hearts in lower vertebrates contain a rudimentary outflow tract but not a right ventricle, the existence and function of SHF-like cells in these species has remained a topic of speculation. By constructing of a set of transgenic fish lines, Zhou et al. provide direct evidence from Cre/Lox-mediated lineage tracing and genetic analysis in zebrafish, that latent TGF-β binding protein 3 (ltbp3) transcripts mark a field of cardiac progenitor cells with defining characteristics of the anterior SHF in mammals. Specifically, ltbp3 cells differentiate in pharyngeal mesoderm after formation of the heart tube, elongate the heart tube at the outflow pole, and give rise to three cardiovascular lineages in the outflow tract and myocardium in the distal ventricle. Their findings uncover a requirement for ltbp3-TGF-β signaling during zebrafish SHF development, a process that serves to enlarge the single ventricular chamber in this species.

2008-2011: Cardiovascular Research Center, Massachusetts General Hospital, Harvard Medical School, Boston, USA), Postdoc Research fellow
2006-2008: Ottawa Health Research Institute, Ottawa Hospital, University of Ottawa, Ottawa, Canada, Postdoc Research fellow
2001-2006: Key laboratory of Marine Drugs, Ministry of Education, P.R. China, Institute of Marine Drugs, Ocean university of China, Qingdao, Pharmacology
2002-2006: Institute of Matria Medica, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China, Pharmacology
1997-2001: Ocean university of China, Qingdao, China. Pharmaceutical Chemistry

Major Academic Appointments
2011-Present: Group leader of development and diseases lab, Institute of Health Science, Shanghai Institutes for Biological Sciences, CAS / Shanghai JiaoTong University of Medicine, China

Recent Publications

  1. Fan HB, Liu YJ, Wang L, Du TT, Dong M, Gao L, Meng ZZ, Jin Y, Chen Y, Deng M, Yang HT, Jing Q, Gu AH, Liu TX, Zhou Y. miR-142-3p acts as an essential modulator of neutrophil development in zebrafish. Blood. 2014 Jul 2 (In press)
  2. Dong ZW, Ren CG, Xia Y, Su D, Du TT, Fan HB, Yuan H, Wang L, Dong M, Li WC, Jin Y, Chen Y, Deng M, Liu TX, Gu AH, Zhou Y. Pten regulates homeostasis and inflammation-induced migration of myelocytes in zebrafish. J Hematol Oncol. 2014,7(1):17.
  3. Wang L, Fu C, Fan H, Du T, Dong M, Chen Y, Jin Y, Zhou Y, Deng M, Gu A, Jing Q, Liu T, Zhou Y. miR-34b regulates multiciliogenesis during organ formation in zebrafish. Development. 2013,140(13): 2755-2764
  4. Jing CB, Chen Y, Dong M, Peng XL, Jia XE, Gao L, Ma K, Deng M, Liu TX, Zon LI, Zhu J, Zhou Y, Zhou Y. Phospholipase C gamma-1 is required for granulocyte maturation in zebrafish. Dev Biol. 2013,374(1):24-31
  5. Zhou Y, Cashman TJ, Nevis K, Obregon P, Carney SA, Liu Y, Gu AH, Mosimann C, Sondalle S, Peterson R, Heideman W, Burns CE, and Burns CG. Latent TGF-b binding protein 3 identifies a second heart field in zebrafish. Nature. 2011, 474, 645-8 (Highlighted)
  6. Zhou Y, Ma C, Karmouch J, Katbi HA, Liu XJ. Antiapoptotic role for ornithine decarboxylase during oocyte maturation. Mol. Cell. Biol. 2009, 29:1786-95
  7. Zhou Y, Liu A, Wang W, Du G. Using the protein chip to screen agonists and antagonists of the androgen receptor. J Biomol Screen. 2008, 13(4):276-84
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