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Principal Investigators

Faculty and Staff

Principal Investigators
PAN Weijun
Ph.D., Principal Investigator
Laboratory of Signal Transduction and Human Diseases

Research Interests or Current Research Focus
1) Study on the regulatory role in Wnt signaling and Phospholipid metabolism interaction
2) Study on the regulatory role of Wnt signaling in vascular morphogenesis, stem cell vascular niche and related diseases
3) Innovate and apply zebrafish research tools and disease models

Major Research Achievement
1) Transcriptional activity-independent regulatory role of Wnt signaling in myogenesis,
2) Role of Wnt-induced PIP2 production in Wnt signalosome formation and signaling transduction,
3) CDS2-controlled PIP2 availability limits VEGFa signaling and angiogenesis.

1995-1999: East China University of Science and Technology, Bachelor
1999-2005: Institute of Biochemistry and Cell Biology, Shanghai Institute of Life Science, Chinese Academy of Science, Ph.D

Major Academic Appointments
2005-2009: Postdoc Department of Pharmacology, School of Medicine, Yale University
2009-2012: Postdoc NICHD, National Institutes of Health
2012-present: Principle Investigator, Institute of Health Sciences, SIBS, CAS / SJTUSM

Honors, Certificates, and Academic Society
2012: Recipient of the Recruitment Program of Global Experts (Young Program)
2010: NIH Fellows Award for Research Excellence
2003: “Young Investigator Award”, 10th East Asian Joint Symposium on Biomedical Research as a Ph.D student)

Recent Publications

  1. Wang S, Yin J, Chen D, Nie F, Song X, Fei C, Miao H, Jing C, Ma W, Wang L, Xie S, Li C, Zeng R, Pan W, Hao X, Li L. Small-molecule modulation of Wnt signaling via modulating the Axin-LRP5/6 interaction. Nat Chem Biol. 2013 Jul 28. [PDF]
  2. Ren CG*, Wang L, Jia XE, Liu YJ, Dong ZW, Jin Y, Chen Y, Deng M, Zhou Y, Zhou Y, Ren RB*, Pan WJ*, Liu TX. Activated N-Ras signaling regulates arterial-venous specification in zebrafish. J Hematol Oncol. 2013 May 12;6(1):34. (* 通讯作者) [PDF]
  3. Wang R, Wang Y, Liu N, Ren C, Jiang C, Zhang K, Yu S, Chen Y, Tang H, Deng Q, Fu C, Wang Y, Li R, Liu M, Pan W, Wang P. FBW7 regulates endothelial functions by targeting KLF2 for ubiquitination and degradation. Cell Res. 2013 Jun;23(6):803-19.
  4. Kim I, Pan W*, Jones SA, Zhang Y, Zhuang X, Wu D*. Clathrin and AP2 are required for PtdIns(4,5)P2-mediated formation of LRP6 signalosomes. (2013) J Cell Biol. 200(4):419-28. (*通讯作者)
  5. Pan W, Pham VN, Stratman AN, Castranova D, Kamei M, Kidd KR, Lo BD, Shaw KM, Torres-Vazquez J, Mikelis CM, Gutkind JS, Davis GE, Weinstein BM. CDP-diacylglycerol synthetase-controlled phosphoinositide availability limits VEGFA signaling and vascular morphogenesis. (2012) Blood. 120(2):489-98.
  6. Rinehart J, Maksimova YD, Tanis JE, Stone KL, Hodson CA, Zhang J, Risinger M, Pan W, Wu D, Colangelo CM, Forbush B, Joiner CH, Gulcicek EE, Gallagher PG, Lifton RP. Sites of regulated phosphorylation that control K-Cl cotransporter activity. (2009) Cell. 138(3):525-36.
  7. Qin Y, Li L, Pan W*, Wu D*. Regulation of phosphatidylinositol kinases and metabolism by Wnt3a and Dvl. (2009) J Biol Chem. 284(34):22544-8. (*通讯作者)
  8. Pan W, Choi SC, Wang H, Qin Y, Volpicelli-Daley L, Swan L, Lucast L, Khoo C, Zhang X, Li L, Abrams CS, Sokol SY, Wu D. Wnt3a-mediated formation of phosphatidylinositol 4,5-bisphosphate regulates LRP6 phosphorylation. (2008) Science. 321(5894):1350-3.
  9. Pan W, Jia Y, Huang T, Wang J, Tao D, Gan X, Li L. Beta-catenin relieves I-mfa-mediated suppression of LEF-1 in mammalian cells. (2006) J Cell Sci. 119(Pt 23):4850-6.
  10. Pan W, Jia Y, Wang J, Tao D, Gan X, Tsiokas L, Jing N, Wu D, Li L. Beta-catenin regulates myogenesis by relieving I-mfa-mediated suppression of myogenic regulatory factors in P19 cells. (2005) Proc Natl Acad Sci U S A. 102(48):17378-83.
  11. Pan WJ, Pang SZ, Huang T, Guo HY, Wu D, Li L. Characterization of function of three domains in dishevelled-1: DEP domain is responsible for membrane translocation of dishevelled-1. (2004) Cell Res. 14(4):324-30.

Invited reviews, comments and book chapters
1. AV Gore, K Monzo, YR Cha, Weijun Pan, Weinstein BM. Vascular development in the zebrafish. Cold Spring Harb Perspect Med. 2012 May;2(5) :a006684.
2. Kamei M, Isogai S, Weijun Pan, Weinstein BM. Imaging blood vessels in the zebrafish. Methods in Cell Biology. 2010;100:27-54. PubMed PMID: 21111213
3. Dianqing Wu, Weijun Pan. GSK3: a multifaceted kinase in Wnt signaling. Trends in Biochemical Sciences. 2009 Oct 31. PubMed PMID: 19884009.

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