Ph.D., Principal Investigator
Laboratory of Lymphocyte Differentiation and Tolerance
Research Interests or Current Research Focus
(1) Signaling transduction of helper T cell differentiation;
(2) The role of RNA and RBP in regulating T cell functions;
(3) Molecular and cellular mechanisms of immune tolerance.
Major Research Achievement
His research is focusing on the molecular mechanisms regulating lymphocyte differentiation. He will use RNA interference screens, in vitro primary lymphocyte culture, mice with targeted alterations of genes, high-throughput sequencing and other technologies to analyze how genes are regulated during lymphocyte differentiation and how malfunction of these processes lead to diseases such as autoimmunity and immune deficiencies. The goal is that the research will provide information that could lead to new therapies based on gene functions.
He obtained his Ph.d degree from Ohio State University, and postdoctoral training at Yale University.
Major Academic Appointments
2012-present: Principle Investigator, Institute of Health Sciences, SIBS, CAS / SJTUSM
Honors, Certificates, and Academic Society
In 2012, he joined the IHS and was selected in 1000 Talent Program(young group)
- Chang X, Liu F, Wang X, Lin A, Zhao H, and Su B 2011. The Kinases MEKK2 and MEKK3 Regulate Transforming Growth Factor-β-Mediated Helper T Cell Differentiation. Immunity. 34(2): 201-212.
- Enzler T, Chang X, Facchinetti V, Melino G, Karin M, Su B, Gallagher E. 2009. MEKK1 Binds HECT E3 Ligase Itch by Its Amino-Terminal RING Motif to Regulate Th2 Cytokine Gene Expression. J Immunol. 183(6): 3831-3838.
- Wang XF, Chang X, Facchinetti V, Zhuang Y,and Su B. 2009. MEK Kinase 3 is essential for lymphopenia-Induced T cell Proliferation and Survival. J Immunol. 182(6):3597-608.
- Chang X, Zheng P, and Liu Y 2009. Selective Elimination of Autoreactive T cells in vivo by the Regulatory T Cells. Clin Immunol. 130(1):61-73.
- Chang X, Zheng P, and Liu Y 2008. Homeostatic proliferation in the mice with germline FoxP3 mutation and its contribution to fatal autoimmunity. J Immunol. 181(4):2399-406.
- Chen GY, Chen C, Wang L, Chang X, Zheng P, Liu Y. 2008. Cutting edge: Broad expression of the FoxP3 locus in epithelial cells: a caution against early interpretation of fatal inflammatory diseases following in vivo depletion of FoxP3-expressing cells. J Immunol. 180(8):5163-6.
- Zuo T, Liu R, Zhang H, Chang X, Liu Y, Wang L, Zheng P, Liu, Y. 2007. FOXP3 is a novel transcriptional repressor for the breast cancer oncogene SKP2. J Clin Invest. 117(12): 3765-73.
- Zuo T, Wang LZ, Morrison C, Chang X, Zhang HM, Yang TY, Wang Y, Liu Y, Zheng P, Liu Y. 2007. FOXP3 is an X-linked breast cancer suppressor gene and an important repressor of the HER-2/ErbB2 oncogene. Cell. 129(7):1275-1286.
- May, K. F., Jr., Chang, X., Zhang, H., Lute, K. D., Zhou, P., Kocak, E., Zheng, P. and Liu, Y. 2007. B7-Deficient Autoreactive T Cells Are Highly Susceptible to Suppression by CD4+CD25+ Regulatory T Cells. J Immunol. 178: 1542-1552.
- Joshi PS, Liu JQ, Wang Y, Chang X, Richards J, Assarsson E, Shi FD, Ljunggren HG, Bai XF. 2006. Cytokine-induced killer T cells kill immature dendritic cells by TCR-independent and perforin-dependent mechanisms. J Leukoc Biol. 80:1345-53.
- Chang X, Chen L, Wen J, Godfrey VL, Qiao G, Hussien Y, Zhang J, Gao JX. 2006. Foxp3 controls autoreactive T cell activation through transcriptional regulation of early growth response genes and E3 ubiquitin ligase genes, independently of thymic selection. Clin Immunol. 121(3):274-85.
- Li O*, Chang X*, Zhang H, Kocak E, Ding C, Zheng P, Liu Y 2006. Massive and destructive T cell response to homeostatic cue in CD24-deficient lymphopenic hosts. J Exp Med. 203: 1713-1720. (* co-first author)
- Kocak E, Lute K, Chang X, May KF Jr, Exten KR, Zhang H, Abdessalam SF, Lehman AM, Jarjoura D, Zheng P, Liu Y 2006. Combination Therapy with Anti-CTL Antigen-4 and Anti-4-1BB Antibodies Enhances Cancer Immunity and Reduces Autoimmunity. Cancer Res. 66: 7276-84.
- Richards J, Chang X, Blaser B, Caligiuri M, Zheng P and Liu Y 2006. Tumor Growth Impedes Natural-Killer Cell Maturation in the Bone Marrow. Blood. 108: 246-52.
- Chang X, Zheng P, and Liu Y 2006. FoxP3, a genetic link between immunodeficiency and autoimmune diseases. Autoimmunity Reviews. 5:399-402.
- Chang X, Gao JX, Jiang Q, Wen J, Seifers N, Su L, Godfrey VL, Zuo T, Zheng P, and Liu Y 2005. The Scurfy mutation of FoxP3 in the thymus stroma leads to defective thymopoiesis. J Exp Med. 202:1141-1151.
- Gao JX, Chang X, Zheng X, Wen J, Yin L, Du P, Zheng P, and Liu Y 2004. A new role for CD28 in the survival of autoreactive T cells in the periphery after chronic exposure to autoantigen. Int Immunol. 16:1403-1409.
- Zheng X, Gao JX, Chang X, Wang Y, Liu Y, Wen J, Zhang H, Zhang J, Liu Y, and Zheng P 2004. B7-CD28 interaction promotes proliferation and survival but suppresses differentiation of CD4-CD8-T cells in the thymus. J Immunol. 173:2253-2261.