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TANG Yun-Chi
Ph.D., Principal Investigator
Laboratory of Cancer Biology & Genetics
Email: yctang@@sibs.ac.cn
 

Research Interests or Current Research Focus
Chromosome mis-segregation leads to cell death or aneuploidy. Unlike single mutation that only influences a limited subset of genes, aneuploidy with gain or loss of entire chromosomes affects numerous genes that participate in a large number of pathways and thus disturb multiple cellular processes at the same time. Our laboratory is interested in understanding how aneuploidy affects cell physiology, and how these aneuploid effects are tolerated, or even become advantageous for cancer cells. Our research covers a range of biochemical, cell biology and mouse genetic approaches, in addressing the signaling alterations and consequences resulted by aneuploidy.

Major Research Achievement
Chromosome mis-segregation leads to cell death or aneuploidy. Unlike single mutation that only influences a limited subset of genes, aneuploidy with gain or loss of entire chromosomes affects numerous genes that participate in a large number of pathways and thus disturb multiple cellular processes at the same time. Our laboratory is interested in understanding how aneuploidy affects cell physiology, and how these aneuploid effects are tolerated, or even become advantageous for cancer cells. Our research covers a range of biochemical, cell biology and mouse genetic approaches, in addressing the signaling alterations and consequences resulted by aneuploidy.

Education
2002-2007: Ph.D., Ludwig-Maxmillians University/ Max-Planck Institute of Biochemistry, Germany.
1997-1999: M.S., National Yang-Ming University, Taiwan
1991-1995: B.S., Soochow University, Taiwan

Major Academic Appointments
2013-Present: Principle Investigator, Institute of Health Sciences, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, China.
2008-2013: Postdoctoral Fellow, Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, USA.
1999-2001: Research Technician, Academia Sinica, Taiwan

Honors, Certificates, and Academic Society
2013: Recipient of the Recruitment Program of Global Experts (Young Program)
2009-2012: Human Frontier Science Program Long-Term Fellow
2007: Max-Planck Institute of Biochemistry Junior Research Award (Germany)

Recent Publications

  1. Santagata, S#., Mendillo, M. L#., Tang, Y-C., Subramanian, A., Perley, C.C., Roche, S.P., Wong, B., Narayan, R., Kwon, H., Koeva, M., Amon, A., Golub, T. R., Porco Jr., J.A., Whitesell, L., and Lindquist, S. (2013) Tight Coordination of Protein Translation and HSF1 Activation Supports the Anabolic Malignant State. Science. 341: 1238303-1-10. #: Equal contribution
  2. Tang, Y-C., and Amon, A. (2013) Gene Copy-Number Alterations: A Cost-Benefit Analysis. Cell. 152(3):394-405.
  3. Tang, Y-C., Williams, B.R., Siegel, J.J., and Amon, A. (2011) Identification of aneuploidy-selective antiproliferation compounds. Cell. 144(4):499-512.
  4. Torres, E.M., Williams, B.R., Tang, Y-C., and Amon, A. (2010) Thoughts on Aneuploidy. Cold Spring Harbor Symposia on Quantitative Biology. 75:445-451.
  5. Tang, Y-C#., Chang, H-C#., Chakraborty, K., Hartl, F.U., and Hayer-Hartl, M. (2008) Essential role of the chaperonin folding compartment in vivo. EMBO J. 27(10):1458-1468. #: Equal contribution
  6. Sharma, S#., Chakraborty, K#., Müller, B.K#., Astola, N., Tang, Y-C., Lamb, D.C., Hayer-Hartl, M., and Hartl, F.U. (2008) Monitoring protein conformation along the pathway of chaperonin-assisted folding. Cell. 133(1):142-153. #: Equal contribution
  7. Chang, H-C., Tang, Y-C., Hayer-Hartl, M., and Hartl, F. U. (2007) SnapShot: Molecular Chaperones, Part I. Cell. 128(1):212.
  8. Tang, Y-C., Chang, H-C., Hayer-Hartl, M., and Hartl, F. U. (2007) SnapShot: Molecular Chaperones, Part II. Cell. 128(2):412.
  9. Tang, Y-C., Chang, H-C., Roeben, A., Wischnewski, D., Wischnewski, N., Kerner, M. J., Hartl, F. U., and Hayer-Hartl, M. (2006) Structural features of the GroEL-GroES nano-cage required for rapid folding of encapsulated protein. Cell. 125(5):903-914.
  10. Lee, Y-C#., Tang, Y-C#., Chen, Y-H#., Wang, C-M., and Tsou, A-P. (2003) Selenite-induced survival of HuH7 hepatoma cells involves activation of focal adhesion kinase-phosphatidylinositol 3-kinase-Akt pathway and Rac1. J Biol Chem. 278(41):39615-39624. #: Equal contribution

Group Members

 
 
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