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Principal Investigators
 
 

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Principal Investigators
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XIAO Yichuan
Ph.D., Principal Investigator
Laboratory of inflammation and molecular immunology
Email: ycxiao@@sibs.ac.cn
 

Research Interests or Current Research Focus
1. Signaling pathway that regulate the activation of neuroglia cells
2. Regulation and molecular mechanism of inflammatory disease
3.Screening and validation of natural compound that regulate inflammatory disease

Major Research Achievement
1.Identify the role of E3 ubiquitin ligase Peli1 in the regulation of microglia activation and inflammation in central nervous system, discover a new molecular mechanism that Peli1 regulate microglia activation (Representative publication: Nature Medicine, 2013).
2. Discover the mechanism of SRC-3-mediated alternative activation of microglia (Representative publications: Glia).
3. Elucidate the role of protein kinase Tpl2 in the regulation of CNS inflammation and IL-17R signaling in astrocyte (Representative publication: Journal of Experimental Medicine).

Education
2010-2014: Postdoctoral fellow, Department of Immunology, MD Anderson Cancer Center, USA
2007-2010: Ph.D., Institute of Health Sciences, SIBS, CAS / Shanghai JiaoTong University School of Medicine, China
2003-2006: M.S., School of Bioengineer, East China University of Sciences and Technology, China
1999-2003: B.S., School of Life Sciences, Hubei University, China.

Major Academic Appointments
2002-till now: Principal Investigator, Institute of Health Sciences, SIBS, CAS / Shanghai JiaoTong University School of Medicine, China
2006-2007: Assistant editor, Shanghai Information Center of Life Sciences, Chinese Academy of Sciences

Honors, Certificates, and Academic Society
2010: Pfizer first-class Prize, SIBS/CAS
2013:MD Anderson Cancer Center, Harold C. and Mary L. Daily Endowment Fellowships
2015:Center of Inflammation and Cancer, Poster Award
2015:MD Anderson Cancer Center, Harold C. and Mary L. Daily Endowment Fellowships

Recent Publications

  1. Xiao Y, Jin J, Chang JH, Hu H, Zhou X, Brittain GC, Wang X, Cheng X, Stansberg C, Torkildsen Ø, Brink R, Sun SC. Peli1 promotes microglia-mediated CNS inflammation by regulating Traf3 degradation. Nature Medicine, 2013, 19: 595-602
  2. Xiao Y, Jin J, Chang M, Nakaya M, Hu H, Zou Q, Zhou X, Brittain GC, Cheng X, Sun SC. TPL2 mediates autoimmune inflammation through activation of the TAK1 axis of IL-17 signaling. J Exp Med. 2014, 211: 1689-1702
  3. Xiao Y*, Sun SC*. Tpl2 mediates IL-17 signaling in neuroinflammation. Oncotarget. In press (* Corresponding)
  4. Xiao Y, Xu J, Mao C, Jin M, Wu Q, Zou J, Gu Q, Zhang Y, Zhang Y. 18β-glycyrrhetinic acid ameliorated Propionibacterium acnes-induced acute liver injury through inhibition of macrophage inflammatory protein-1α. J Biol Chem. 2010, 285: 1128-1137
  5. Xiao Y#, Xu J#, Wang S, Mao C, Jin M, Ning G, Xu J, Zhang Y. Genetic ablation of steroid receptor coactivator-3 promotes PPAR-β-mediated alternative activation of microglia/macrophages in experimental autoimmune encephalomyelitis. Glia. 2010, 58: 932-942 (# Equal contribution)
  6. Xiao Y, Zhang Y. Suppressor of cytokine signaling-1, a possible cause for regulatory T cells in hepatitis? Hepatology. 2008, 48:1353.
  7. Xiao Y, Jin J, Zou Q, Hu H, Cheng X, Sun SC. Peli1 negatively regulates type I interferon induction and antiviral immunity in the CNS. Cell Biosci. 2015, 5:34.
  8. Jin J, Xiao Y, Chang JH, Yu J, Hu H, Starr R, Brittain GC, Chang M, Cheng X, Sun SC. The kinase TBK1 controls IgA class switching by negatively regulating noncanonical NF-κB signaling. Nat Immunol. 2012, 13:1101-1109.
  9. Chang JH, Xiao Y, Hu H, Jin J, Yu J, Zhou X, Wu X, Johnson HM, Akira S, Pasparakis M, Cheng X, Sun SC. Ubc13 maintains the suppressive function of regulatory T cells and prevents their conversion into effector-like T cells. Nat Immunol. 2012, 13:481-490.
  10. Nakaya M, Xiao Y, Zhou X, Chang JH, Chang M, Cheng X, Blonska M, Lin X, Sun SC. Inflammatory T Cell Responses Rely on Amino Acid Transporter ASCT2 Facilitation of Glutamine Uptake and mTORC1 Kinase Activation. Immunity. 2014, 40: 692-705
  11. Jin J, Xiao Y, Hu H, Zou Q, Li Y, Gao Y, Ge W, Cheng X, Sun SC. Proinflammatory TLR signalling is regulated by a TRAF2-dependent proteolysis mechanism in macrophages. Nat Commun. 2015, 6:5930.
  12. Romano S, Xiao Y, Nakaya M, D’Angelillo A, Chang M, Jin J, Felix Hausch4, Masullo M, Feng X, Romano MF, Sun SC. FKBP51 employs both scaffold and isomerase functions to promote NF-kB activation in melanoma. Nucleic Acids Res. 2015, In press
  13. Zou Q, Jin J, Xiao Y, Hu H, Zhou X, Li J, Cheng X, Jie Z, Xie X. T cell development involves TRAF3IP3-mediated ERK signaling in the Golgi. J Exp Med. 2015, In press
  14. Chang M, Jin W, Chang JH, Xiao Y, Brittain GC, Yu J, Zhou X, Wang YH, Cheng X, Li P, Rabinovich BA, Hwu P, Sun SC. The ubiquitin ligase Peli1 negatively regulates T cell activation and prevents autoimmunity. Nat Immunol. 2011, 12:1002-1009.
  15. Hu H, Brittain GC, Chang JH, Puebla-Osorio N, Jin J, Zal A, Xiao Y, Cheng X, Chang M, Fu YX, Zal T, Zhu C, Sun SC. OTUD7B controls non-canonical NF-κB activation through deubiquitination of TRAF3. Nature. 2013, 494:371-374
  16. Jin J, Hu H, Li HS, Yu J, Xiao Y, Brittain GC, Zou Q, Cheng X, Mallette FA, Watowich SS, Sun SC. Noncanonical NF-κB Pathway Controls the Production of Type I Interferons in Antiviral Innate Immunity. Immunity. 2014, 40:342-354
  17. Zou Q, Jin J, Hu H, Li HS, Romano S, Xiao Y, Nakaya M, Zhou Xi, Cheng X, Yang P, Lozano G, Zhu C, Watowich SS, Ullrich SE, Sun SC. USP15 stabilizes MDM2 to mediate cancer cell survival and inhibit antitumor T-cell responses. Nat Immunol. 2014 Jun;15(6):562-70.
  18. Chang JH, Hu H, Jin J, Puebla-Osorio N, Xiao Y, Blink R, Ullrich SE, Sun SC. TRAF3 regulates follicular regulatory T cell induction and humoral immune responses. J Exp Med. 2014, 211:137-151
  19. Jin J, Xiao Y, Hu H, Zou Q, Li Y, Cheng X, Sun SC. Proinflammatory TLR signaling is regulated by a TRAF2-dependent proteolysis mechanism in macrophages. Nat Comm. 2015 Jan 7;6:5930.
  20. Xu J, Zhang Y, Xiao Y, Ma S, Liu Q, Dang S, Jin M, Shi Y, Wan B, Zhang Y. Inhibition of 12/15-lipoxygenase by baicalein induces microglia PPARβ/δ: a potential therapeutic role for CNS autoimmune disease. Cell Death Dis. 2013, 4: e569
  21. Mao C, Wang S, Xiao Y, Xu J, Jiang Q, Jin M, Jiang X, Guo H, Ning G, Zhang Y. Impairment of regulatory capacity of CD4+CD25+ regulatory T cells mediated by dendritic cells polarization and hyperthyroidism in Graves’ disease. J Immunol. 2011, 186: 4734-4743.
  22. Gu Q, Wu Q, Jin M, Xiao Y, Xu J, Mao C, Zhao F, Zhang Y, Zhang Y. Heme oxygenase-1 alleviates mouse hepatic failure through suppression of adaptive immune responses. J Pharmacol Exp Ther. 2012, 340:2-10.
  23. Zhang C#, Hao L#, Wang L#, Xiao Y#, Ge H, Zhu Z, Luo Y, Zhang Y, Zhang Y. Elevated IGFIR expression regulating VEGF and VEGF-C predicts lymph node metastasis in human colorectal cancer. BMC Cancer. 2010, 10:184. (# Equal contribution)
  24. Wang S, Mao C, Zhao Z, Gu Q, Jin M, Xiao Y, Jiang X, Zhao Y, Zhang Y, Ning G. Increased TTS abrogates IDO-mediated CD4+ T cells suppression in patients with Graves’ disease. Endocrine. 2009, 36: 119-125.
  25. Zhou T, Zhang Y, Sun G, Zou J, Li X, Cai M, Xiao Y, Zhang Y, Zhao Y, Chen N. PsL-EGFmAb inhibits the stimulatory functions of human dendritic cells via DC-SIGN. Front Biosci. 2008; 13: 7269-7276.
  26. Xiao Y, Zhou Y, Wang J, Yu M, Wang G, Jin J, Xiao J. Selection and identification of human gonadotropin-releasing hormone promoter binding peptides by phage display-CEMSA. J MolRecognit. 2007, 20: 51-57.
 
 
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