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Principal Investigators
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YANG Huangtian
Ph.D., Professor, Principal Investigator
Laboratory of Molecular Cardiology
Key Laboratory of Stem Cell Biology, CAS

Email: htyang@@sibs.ac.cn
 

Research Interests or Current Research Focus
The long-term goal of Dr. Yang′s lab is to identify the mechanisms that underlie the physiological and pathological alterations in cardiac contractile function, and to develop novel targets and therapeutic strategies related to prevention and treatment of ischemic diseases and heart failure. The lab is currently conducting the researches in the following aspects:

1. Identify regulatory mechanisms underlying differentiation of pluripotent stem cells, especially the decision of cardiomyocyte fate;
2. Characterize pluripotent stem cell-derived cardiomyocytes and explore their implication in myocardial regeneration and drug screen;
3. Elucidate the regulatory mechanisms of Ca2+ signaling and the signal transduction pathways mediated by G protein coupled receptors in cardiogenesis and in myocardial contraction;
4. Determine the new effect and mechanisms of intermittent hypoxic adaptation-, natural compounds- and endogenous factors-induced cardioprotection gainst ischemic injury and explore their potential therapeutic significance.

Major Research Achievement
1. Established murine and human embryonic stem cell (ESCs) and induced pluripotent stem cell (iPSCs) culture, differentiation, and analysis systems in the laboratory; established effective cardiomyocyte differentiation system from ESCs including rat ESCs and iPSCs;
2. Using embryonic stem cell-derived cardiomyocytes as in vitro model of cardiomyogenesis, together with gene mutation and pharmacological approaches, we demonstrate the importance of Ca2+ signaling in the regulation of ESC differentiation and function of ESC-derived cardiomyocytes. We revealed that functional sarcoplasmic reticulum (SR) and Ca2+ release channel/type 2 ryanodine receptor (RyR2)-mediated SR Ca2+ release directly contribute to the beating rate regulation, spontaneous and β-adrenergic receptor-stimulated contraction of ESC-derived cardiomyocytes even at very immature stages of development, and specific neuronal cell differentiation; we also found that type 3 IP3R plays a key role in the mesoderm fate decision via regulation of apoptosis;
3. We demonstrate that adaptation to intermittent hypoxia has strong cardioprotection against lethal Ca2+ overload and ischemia/reperfusion injury though preservation of Ca2+ homeostasis and maintenance of myofilament stability via its protection on SR, Na+/Ca2+ exchange and mitochondria as well as via its inhibition on μ-calpin activity. These protections are mediated by Akt/PI3K, PKCε and CaMKII pathways and ROS signaling. More recently, we found that intermittent hypoxia can mitigate the deleterious consequences of sustained myocardial ischemia. However, if substantiated. These data raise the intriguing possibility that a relatively simple intervention - intermittent exposure to simulated altitude, initiated days after coronary artery occlusion - may offer profound benefit to patients with acute myocardial infarction.
4. We revealed new effects and mechanisms of α1-adrenergic receptor subtype and heat shock protein 27 in the cardioprotection against I/R injury via preservation of mitochondrial function and maintenance of myofilament stability.

Education
1978 - 1982: B.S., Medicine, School of Medicine, Nantong University, China
1985 - 1988: M.D., Su Zhou Medical College, China
1992 - 1994: Ph.D., Department of Pharmacology at Yamagata University, School of Medicine, Japan

Major Academic Appointments
1982 - 1985: Instructor, Nantong University, China
1989 - 1992: Assistant Professor, Nantong University, China
1992 - 1997: Instructor, research fellow, Dept. of Pharmacology, Yamagata University School of Medicine, Japan
1997 - 2001: Researcher fellow, Laboratory of Cardiovascular Science, Gerontology Research Center, NIA, NIH, USA
2000 - : Principal Investigator, Laboratory of Molecular Cardiology in Institute of Health Sciences, SIBS, CAS/SJTUSM, China
2003 - 2004: Director Assistant, Institute of Health Sciences, SIBS, CAS/SJTUSM, China
2005 - : Associate Director, Institute of Health Sciences, SIBS, CAS/SJTUSM, China
2006 - : Principal Investigator, Key Laboratory of Stem Cell Biology, SIBS, China

Honors, Certificates, and Academic Society
Chinese Society of Medicine in Cardiovascular Diseases (1990)
2nd Award of Science and Technology Progress in Nantong (1990)
Weihala Scholarship (1993-1995)
Japanese Society of Pharmacology (1993-1997)
Chinese Academy of Sciences "Hundred Talents" (2000)
Chinese Society of High Altitude Medicine (Council member, 2000-)
Fellows Award for Research Excellence from National Institutes of Health (2001)
Chinese Association for Physiological Sciences Circulation Committee (Council member, 2004-)
Shanghai Society for Physiological Sciences (Vice Chairman, 2006-)
Chinese Association of Pathophysiology, Cardiovascular Sciences and Recept and Signal Transduction professional Committee (Council member, 2004-)
Chinese and Shanghai Society for Cell Biology (Council member, 2007-)
The International Society for Heart Research-China Section (Vice Chairman, 2008-)
American Heart Association/American Stroke Association Professional Membership (2009-)
Biophysical Society Membership (2010)

Recent Publications

  1. Wang YJ, Huang J, Liu W, Kou X, Tang H, Wang H, Yu X, Gao S, Ouyang K, Yang HT. IP3R-mediated Ca2+ signals govern hematopoietic and cardiac divergence of Flk1+ cells via the calcineurin-NFATc3-Etv2 pathway. J Mol Cell Biol. 2017 Apr 13. doi: 10.1093/jmcb/mjx014. [Epub ahead of print]
  2. Zheng Y, Gu S, Li X, Tan J, Liu S, Jiang Y, Zhang C, Gao L, Yang HT*. Berbamine postconditioning protects the heart from ischemia/reperfusion injury through modulation of autophagy. Cell Death Dis. 2017 Feb 2;8(2):e2577. doi: 10.1038/cddis.2017.7.
  3. Lu J, Kaestle K, Huang J, Liu Q, Zhang P, Gao L, Gardiner J, Thissen H, Yang HT*. Interactions of human embryonic stem cell-derived cardiovascular progenitor cells with immobilized extracellular matrix proteins. J Biomed Mater Res A. 2017 Jan 13. doi: 10.1002/jbm.a.36005.
  4. Ma R, Liang J, Huang W, Guo L, Cai W, Wang L, Paul C, Yang HT, Kim HW, Wang Y. Electric stimulation enhances cardiac differentiation of human induced pluripotent stem cells for myocardial infarction therapy. Antioxid Redox Signal. 2017 Jan 12. doi: 10.1089/ars.2016.6766.
  5. Wang Z, Zhang XJ, Ji YX, Zhang P, Deng KQ, Gong J, Ren S, Wang X, Chen I, Wang H, Gao C, Yokota T, Ang YS, Li S, Cass A, Vondriska TM, Li G, Deb A, Srivastava D, Yang HT, Xiao X, Li H, Wang Y. The long noncoding RNA Chaer defines an epigenetic checkpoint in cardiac hypertrophy. Nat Med. 2016 Oct;22(10):1131-1139.
  6. Huang J, Zhang M, Zhang P, Liang H, Ouyang K, Yang HT*. Coupling switch of P2Y-IP3 receptors mediates differential Ca2+ signaling in human embryonic stem cells and derived cardiovascular progenitor cells. Purinergic Signal. 2016 Sep;12(3):465-78.
  7. Tang Y, Hong YZ, Bai HJ, Wu Q, Chen CD, Lang JY, Boheler KR, Yang HT*. PHF8 regulates mesodermal and cardiac differentiation of embryonic stem cells through mediating the histone demethylation of pmaip1. Stem Cells. 2016 Jun;34(6):1527-40.
  8. Wu L, Tan JL, Wang ZH, Chen YX, Gao L, Liu JL, Yun-Hua S, Endoh M, Yang HT*. ROS generated during early reperfusion contribute to intermittent hypobaric hypoxia-afforded cardioprotection against postischemia-induced Ca2+ overload and contractile dysfunction via the JAK2/STAT3 pathway. J Mol Cell Cardiol. 2015 Apr;81:150-61.
  9. Chen YX, Liu JL, Zheng YJ, Wang JX, Wang ZH, Gu SS, Tan JL, Jing Q, Yang HT*. Uncoupling Protein 3 Mediates H2O2 Preconditioning-Afforded Cardioprotection through the Inhibition of MPTP Opening. Cardiovasc Res. 2015 Feb 1;105(2):192-202.
  10. Ling Gao, Yan-Jun Zheng, Shan-Shan Gu, Ji-Liang Tan, Christian Paul, Yi-Gang Wang, Huang-Tian Yang*. Degradation of cardiac myosin light chain kinase by matrix metalloproteinase-2 contributes to myocardial contractile dysfunction during ischemia/reperfusion. J Mol Cell Cardiol. 2014 Dec;77:102-112.
  11. 陈斐,陈忠炎,杨黄恬*. microRNA在胚胎干细胞分化的心肌细胞中的表达变化. 生理学报. 2014 Dec 25;66(6): DOI: 10.13294/j.aps.2014.0013.
  12. Wang ZH, Liu JL, Wu L, Yu Z, Yang HT*. Concentration-dependent wrestling between detrimental and protective effects of H2O2 during myocardial ischemia/reperfusion. Cell Death Dis. 2014 Jun 19; 5:e1297.
  13. Tang Y, Chen ZY, Hong YZ, Wu Q, Lin HQ, Chen CD, Yang HT*. Expression profiles of histone lysine demethylases during cardiomyocyte differentiation of mouse embryonic stem cells. Acta Pharmacol Sin. 2014 Jul; 35(7):899-906.
  14. Gao L, Chen L, Lu ZZ, Gao H, Wu L, Chen YX, Zhang CM, Jiang YK, Jing Q, Zhang Y, Yang HT*. Activation of α1B-adrenoceptors contributes to intermittent hypobaric hypoxia-improved post-ischemic myocardial performance via inhibiting MMP-2 activation. Am J Physiol Heart Circ Physiol. 2014 Jun 1;306(11):H1569-81.
  15. Li W, Wang YP, Gao L, Zhang PP, Zhou Q, Xu QF, Zhou ZW, Guo K, Chen RH, Yang HT, Li YG. Resveratrol protects rabbit ventricular myocytes against oxidative stress-induced arrhythmogenic activity and Ca2+ overload. Acta Pharmacol Sin. 2013 Sep;34(9):1164-73.
  16. Huang W, Dai B, Wen Z, Millard RW, Yu XY, Luther K, Xu M, Zhao TC, Yang HT, Qi Z, Lasance K, Ashraf M, Wang Y. Molecular strategy to reduce in vivo collagen barrier promotes entry of NCX1 positive inducible pluripotent stem cells (iPSC(NCX1+)) into ischemic (or injured) myocardium. PLoS One. 2013 Aug 21;8(8):e70023.
  17. Cao N, Liang H, Huang J, Wang J, Chen Y, Chen Z, Yang HT*. Highly efficient induction and long-term maintenance of multipotent cardiovascular progenitors from human pluripotent stem cells under defined conditions. Cell Res. 2013 Sep;23(9):1119-32.
  18. Zhang CM, Gao L, Zheng YJ, Yang HT*. Berbamine Protects the Heart From Ischemia/Reperfusion Injury by Maintaining Cytosolic Ca2+ Homeostasis and Preventing Calpain Activation. Circ J. 2012;76(8):1993-2002.
  19. Wang ZH, Cai XL, Wu L, Zhuo Y, Liu JL, Zhou ZN, Liu JK, Yang HT*. Mitochondrial Energy Metabolism Plays a Critical Role in the Cardioprotection Afforded by Intermittent Hypobaric Hypoxia. Exp Physiol. 2012 Oct;97(10):1105-18.
  20. Wang J, Cao N, Yuan M, Cui H, Tang Y, Qin LJ, Huang X, Shen N, Yang H*. MicroRNA-125b/Lin28 pathway contributes to the mesendodermal fate decision of embryonic stem cells. Stem Cells Dev. 2012 Jun 10;21(9):1524-37.
  21. Cao N, Liu Z, Chen Z, Wang J, Chen T, Zhao X, Ma Y, Qin L, Kang J, Wei B, Wang L, Jin Y, Yang HT*. Ascorbic acid enhances the cardiac differentiation of induced pluripotent stem cells through promoting the proliferation of cardiac progenitor cells. Cell Res. 2012 Jan;22(1):219-36.
  22. Wang ZH, Chen YX, Zhang CM, Wu L, Yu Z, Cai XL, Guan Y, Zhou ZN, Yang HT*. Intermittent Hypobaric Hypoxia Improves Post-ischemic Recovery of Myocardial Contractile Function via Redox Signaling during Early Reperfusion. Am J Physiol Heart Circ Physiol. 2011 Oct;301(4):H1695-705.
  23. Zhang CM, Gao L, Zheng YJ, Yang HT*. Berbamine Increases Myocardial Contractility via a Ca2+-independent Mechanism. J Cardiovasc Pharmacol. 2011 Jul; 58(1):40-8.
  24. Yan L, Jia Z, Cui J, Yang H, Yang H, Zhang Y, Zhou C. Beta-adrenergic signals regulate cardiac differentiation of mouse embryonic stem cells via mitogen-activated protein kinase pathways. Dev Growth Differ. 2011 Aug;53(6):772-9. doi: 10.1111/j.1440-169X.2011.01284.x.
  25. Cao N, Liao J, Liu Z, Zhu W, Wang J, Liu L, Yu L, Xu P, Cui C, Xiao L, Yang HT*. In vitro differentiation of rat embryonic stem cells into functional cardiomyocytes. Cell Res. 2011 Sep;21(9):1316-31. doi: 10.1038/cr.2011.48.
  26. Xu WQ, Yu Z, Xie Y, Huang GQ, Shu XH, Zhu Y, Zhou ZN, Yang HT*. Therapeutic effect of intermittent hypobaric hypoxia on myocardial infarction in rats. Basic Res Cardiol. 2011 May;106(3):329-42.
  27. Liang J, Wang YJ, Tang Y, Cao N, Wang J, Yang HT. Type 3 inositol 1,4,5-trisphosphate receptor negatively regulates apoptosis during mouse embryonic stem cell differentiation. Cell Death Differ. 2010 Jul;17(7):1141-54.
  28. Yu Z, Wang ZH, Yang HT*. Calcium/calmodulin-dependent protein kinase II mediates cardioprotection of intermittent hypoxia against ischemic-reperfusion-induced cardiac dysfunction. Am J Physiol Heart Circ Physiol. 2009 Aug;297(2):H735-42.
  29. Guo A, Yang HT*. Ca2+ removal mechanisms in mouse embryonic stem cell-derived cardiomyocytes. Am J Physiol Cell Physiol. 2009 Sep;297(3):C732-41.
  30. Yang WW, Shu B, Zhu Y, Yang HT. E2F6 Inhibits Cobalt Chloride-Mimetic Hypoxia-induced Apoptosis through E2F1. Mol Biol Cell. 2008 Sep;19(9):3691-700. (cover article)
  31. Xi-Yuan Lu, Le Chen, Xiao-Long Cai, Huang-Tian Yang. Overexpression of heat shock protein 27 against ischemia/reperfusion-induced cardiac contractile dysfunction via stabilization of troponin I and troponin T. Cardiovasc Res. 2008 Aug 1;79(3):500-8.
  32. Hui-Mei Yu, Jing Wen, Rong Wang, Wan-Hua Shen, Shumin Duan, Huang-Tian Yang. Critical role of type 2 ryanodine receptor in mediating activing-depent neurogensis from embryonic stem cells. Cell Calcium. 2008 Jun;43:417-431.
  33. Rong Wang, Ji Liang, Lianju Qin and Huang-Tian Yang. Promoter-dependent EGFP expressions during embryonic stem cell propagation and differentiation. Stem Cells Dev. 2008 Apr;17(2):279-89.
  34. Shu B, Yang WW, Yang HT. Expression pattern of E2F6 in physical and chemical hypoxia-induced apoptosis. Sheng Li Xue Bao. 2008 Feb 25;60(1):1-10.
  35. Gao H, Chen L, Yang HT. Activation of alpha(1B)-adrenoceptors alleviates ischemia/reperfusion injury by limitation of mitochondrial Ca(2+) overload in cardiomyocytes. Cardiovasc Res. 2007 Aug 1;75(3):584-95.
  36. Li J, Zhang H, Zhu WZ, Yu Z, Guo A, Yang HT, Zhou ZN. Preservation of the pHi during ischemia via PKC by intermittent hypoxia. Biochem Biophys Res Commun. 2007 May 4;356(2):329-33.
  37. Yang WW, Wang ZH, Zhu Y, Yang HT. E2F6 negatively regulates ultraviolet-induced apoptosis via modulation of BRCA1. Cell Death Differ. 2007 Apr;14(4):807-817.
  38. Jidong Fu, Huimei Yu, Rong Wang, Ji Liang, Huangtian Yang. Developmental regulation of intracellular calcium transients during cardiomyocyte differentiation of mouse embryonic stem cells. Acta Pharmacol Sin. 2006 Jul;27(7):901-10.
  39. Li Li; Fa-Bao Zhang; Ping-Jin Gao; Huang-Tian Yang, Ding-Liang Zhu. Rat bone- marrow mesenchymal stem cells differentiate into cardiomyocyte-like cells under diverse conditions in vitro. Mol Cardiol China. 2006 Jun; 6(3):153-156.
  40. Le Chen, Xi-Yuan Lu, Jun Li, Ji-Dong Fu, Zhao-Nian Zhou, Huang-Tian Yang. Intermittent hypoxia protects cardiomyocytes against I/R-induced alterations in Ca2+ homeostasis and contraction via the SR and Na+/Ca2+ exchange mechanisms. Am J Physiol Cell Physiol. 2006 Apr;290(4):C1221-9.
  41. Jidong Fu, Jun Li, David Tweedie, Huimei Yu, Le Chen, Rong Wang, Daniel R. Riordon, Sheryl A. Brugh, Shiqiang Wang, Kenneth R. Boheler, Huangtian Yang. Crucial role of the sarcoplasmic reticulum in the developmental regulation of Ca2+ transients and contraction in cardiomyocytes derived from embryonic stem cells. FASEB J. 2006 Jan;20(1):181-3.
  42. W-Z Zhu, Y Xie, L Chen, H-T Yang, and Z-N Zhou. Intermittent high altitude hypoxia inhibits opening of mitochondrial permeability transition pores against reperfusion injury. J Mol Cell Cardiol. 2006 Jan;40(1):96-106.
  43. Zhang FB, Li L, Fang B, Zhu DL, Yang HT, Gao PJ. Passage-restricted differentiation potential of mesenchymal stem cells into cardiomyocyte-like cells. Biochem Biophys Res Commun. 2005 Oct 28;336(3):784-92.
  44. Hong Chen, Xiyuan Lu, Liang Zhu, Liping Wang, Huangtian Yang, Hongzhuan Chen, Wenjun Yuan. Phosphorylated heat shock protein 27 is involved in enhanced heart tolerance to ischemia in short-term type 1 diabetic rats. Acta Pharmacol Sin. 2005 Jul;26(7):806-12.
  45. Xie Y, Zhu Y, Zhu WZ, Chen L, Zhou ZN, Yuan WJ, Yang HT. Role of dual-site phospholamban phosphorylation in intermittent hypoxia-induced cardioprotection against ischemia-reperfusion injury. Am J Physiol Heart Circ Physiol. 2005 Jun;288(6):H2594-602.
  46. Hailei Ding, Haifeng Zhu, Jianwen Dong, Weizhong Zhu, Weiwei Yang, Huangtian Yang, Zhaonian Zhou. Inducible nitric oxide synthase contributes to intermittent hypoxia against ischemia/reperfusion injury. Acta Pharmacol Sin. 2005 Mar;26(3):315-22.
  47. Yan Xie, Weizhong Zhu, Zhaonian Zhou, Zhu Yi, Huangtian Yang. Intermittent high altitude hypoxia protects the heart against lethal Ca2+ overload injury. Life Sci. 2004 Dec 17;76(5):559-72.
  48. Weizhong Zhu, Jianeen Dong, Hailei Ding, Huangtian Yang, Zhaonian Zhou. Postnatal development in intermittent hypoxia enhances resistance to myocardial ischemia/reperfusion in male rats. Eur J Appl Physiol. 2004 May;91(5-6):716-22.
  49. Anna M. Wobus, K Guan, Huang-Tian Yang & Kenneth R. Boheler. Embryonic stem cells as a model to study cardiac,skeletal muscle,and vascular smooth muscle cell differentiation. Methods in Molecular Biology, 2002;Vol. 185:127-156.
  50. Huang-Tian Yang, David Tweedie, Su Wang, Antonio Guia, Tatiana Vinogradova, Konstantin Bogdanov, Paul D. Allen, Michael D. Stern, Edward G. Lakatta and Kenneth R. Boheler. The ryanodine receptor modulates the spontaneous beating rate of cardiomyocytes during development. Proc. Natl. Acad. Sci. USA. 99: 9225-9230, 2002.
  51. Koban MU, Brugh SA, Riordon DR, Dellow KA, Yang HT, Tweedie D, Boheler KR. A distant upstream region of the rat multipartite Na(+)-Ca(2+) exchanger NCX1 gene promoter is sufficient to confer cardiac-specific expression. Mech Dev. 109(2):267-79, 2001.
  52. Huangtian Yang, Kiyoharu sakurai, Hiromi Sugawara, Tomoo Watanabe, Ikuo Norota & Masao Endoh. Contribution of Na+/Ca2+ exchange to the endothelin-1-induced increases in Ca2+ transient and contractility in rabbit ventricular cardiac myocytes: pharmacological analysis with KB-R7943. Br J Pharmacol. 126:1785-1795, 1999.
  53. Michail D Stern, Longsheng Song, Heping Cheng, James SK Sham, Huangtian Yang, Kenneth R. Boheler and Eduardo Rios. Local control models of cardiac excitation-contraction coupling: a possible role for allosteric interactions between ryanodine receptors. J Gen Physiol. 113:469-489, 1999.
  54. Endoh M, Maruya J, Norota I, Yang HT, Talukder MA Hassan, Watanabe T, Sakurai K. Cardiac effects of endothelin: difference between signal myocytes and intact ventricular myocardium. Current Topics in Pharmacology. 4:293-300, 1998.
  55. Masao Endoh, Shinji Fujita, Huang-Tian Yang, M.A. Hassan Talukder, Jun Maruya and Ikuo Norota. Endothelin: recetpor subtypes, signal transduction, regulation of Ca2+ transients and contractility in rabbit ventricular myocardium. Life Sciences. 62(17/18):1485-1489, 1998.
  56. Y Zhu, HT Yang & M Endoh. Does nitric oxide contribute to the negative choronotropic and inotropic effects of endothelin-1 in the heart? Eur J Pharmacol. 332:195-199, 1997.
  57. Huang-Tian Yang & Masao Endoh. Pharmacological evidence for a1D-adrenoceptors in the rabbit ventricular myocardium: analysis with BMY 7378. Br J Pharmacol. 122:1541-1550, 1997.
  58. Yi Zhu, Huang-Tian Yang and Masao Endoh. Negative chronotropic and inotropic effects of endothelin isopeptides in mammalian cardiac muscle. Am J Physiol. 273 (Heart Circ. Physiol. 42): H119-H127, 1997.
  59. Huang-Tian Yang, Yi Zhu and Masao Endoh. Species-dependent differences in inotropic effects and phosphoinositide hydrolysis induced by endothelin-3 in relation to specific binding sites in mammalian ventricular myocardium. Br J Pharmacol. 120: 1497-1504, 1997.
  60. Huang-Tian Yang & Masao Endoh. (±)-Tamsulosin, an a1A-adrenoceptor antagonist, inhibits the positive inotropic effect but not the accumulation of inositol phosphates in rabbit heart. Eur J Pharmacol. 312(3):281-291, 1996.
  61. Masao Endoh, Ikuo Norota, Huang-Tian Yang, Shinji Fujita and Masahiro Takanashi. Positive inotropic effect and the hydrolysis of phosphoinositide induced by endothelin-3 in rabbit ventricular myocardium: inhibition by a selective antagonist of ETA receptors, FR139317. J Pharmacol Exp Ther. 277(1): 61-71, 1996.
  62. Huang-Tian Yang, Ikuo Norota, Yi Zhu and Masao Endoh. Methoxamine-induced inhibition of the positive inotropic effect of endothelin via a1-adrenoceptors in the rabbit heart. Eur J Pharmacol. 296(1):47-54, 1996.
  63. Huang-Tian Yang, Ikuo Norota, Yi Zhu and Masao Endoh. Mechanisms for the inhibitory action of methoxamine on the receptor-mediated inotropic response. Heart. 27(Suppl. 2):16-19, 1995.
  64. Huang-Tian Yang, Ikuo Norota and Masao Endoh. Positive inotropic effect and acceleration of phosphoinositide hydrolysis by methoxamine. Heart. 26(Suppl. 4):24-28, 1994.
  65. Yang Huang-Tian, Yang Yu-Lin. Study of alpha-1 adrenoceptors in heart: mechanisms of positive inotropic effects and receptor subtypes. Chinese Pharmacological Bulletin. 10:411-414, 1994.
  66. Huang-Tian Yang and Masao Endoh. Dissociation of the methoxamine-induced positive inotropic effect and phosphoinositide hydrolysis in rabbit ventricular myocardium: comparison with phenylephrine and alpha-1 adrenoceptor subtype involved. J Pharmacol Exp Ther. 269(2):732-742, 1994.
  67. Kohi M, Yang HT, Endoh M. Myocardial a1A-adrenoceptor subtypes in rabbit: differentiation by a selective antagonist, HV723. Eur J Pharmacol. 250: 95-101, 1993.
  68. Yang, Huang-Tian., Yang, Yu-Lin., Peng, Si-Xun. and Huang, Wen-Long. Hypotensive effect of naphthylmethyl isoquinoline. Acta Pharmaceutica Sinica. 25(7):551-554, 1990.
  69. Yang, Huang-Tian., Yang, Yu-Lin. Effect of naphthylmethyl isoquinoline on the isolated guinea pig myocardium. Acta Pharmaceutica Sinica. 25(7):485-489, 1990.

Invited reviews, comments and book chapters
评述与综述
1. Xinyang Hu, HuangTian Yang, Yuangui Zhu, Jian’an Wang, Erdan Dong. Chinese Basic Cardiovascular Research in Transition. Circ Res. 2016 Jun 10;118(12):1876-9. doi: 10.1161/CIRCRESAHA.116.308063.(viewpoint)
2. Yang HT*, Zhang M, Huang JJ, Liang H, Zhang P, Boheler KR. Cardiomyocytes derived from pluripotent stem cells: progress and prospects from China. Exp Cell Res. 2013 Jan 15;319(2):120-5. doi: 10.1016/j.yexcr.2012.09.011.
3. Feng Y, Wang Y, Cao N, Yang H, Wang Y* Progenitor/stem cell transplantation for repair of myocardial infarction: Hype or hope? Ann Palliat Med. 2012;1(1):65-77.
4. Yang HT* Adaptation to Intermittent Hypoxia Protects the Heart from Ischemia/Reperfusion Injury and Myocardial Infarction. Science Suppl. 2012.P47-48. ( http://www.sciencemag.org/site/products/index.xhtml)
5. 梁贺, 王嘉, 曹楠, 黄吉均, 杨黄恬. 胚胎干细胞及诱导多能干细胞向心肌细胞分化和调控的研究进展. 生命科学. 21(5): 663-668, 2009
6. Huang-Tian Yang and Chao-Shu TAN. Spotlight on cardioprotection against ischemia-reperfusion injury (Editorial Comment). Acta Physiologica Sinica Special Issue on Cardiovascular Injury and Protection. 59(5):540-541, 2007
7. Zhang Yi, Yang HT, Zhou ZN. The Cardioprotection of intermittent hypoxic adaptation. Acta Physiologica Sinica. 59 (5): 601-613, 2007
8. Ji-Dong Fu, Huang-Tian Yang. Developmental regulation of intracellular calcium homeostasis in early cardiac myocytes. Acta Physiologica Sinica, 58(2):95-103, 2006
9. Zhang FB, Yang HT. Plasticity of bone marrow mesenchymal stem cells differentiating into cardiomyocytes and the potential of cardiac therapeutics. Progress in Physiological Sciences. 37(3):199-204, 2006
10. Yang, Huang-Tian. Stem Cells. Science (Chinese) 57(5):54-55, 2005
11. Yang, Huang-Tian. Stem Cells: Hot Field in life science. Science (Chinese) 54(3):12-14, 2002
12. KR Boheler, J Czyz, D Tweedie, Huang-Tian Yang, Anisimov S.V., Wobus A.W. Differentiation of pluripotent embryonic stem cells into cardiomyocytes. Circ. Res. 91:189-201, 2002.
13. Endoh M, Maruya J, Norota I, Yang H-T, Talukder M A, Hassan, Watanabe T, Sakurai K. Cardiac effects of endothelin: difference between signals in myocytes and intact ventricular myocardium. Current Topics in Pharmacology. 4: 293-300, 1998.
14. Yang Huang-Tian., Yang Yu-Lin. Study of alpha-1 adrenoceptors in heart: mechanisms of positive inotropic effects and receptor subtypes. Chinese Pharmacological Bulletin. 1994; 10:411-414.

专著
1. 张海峰、高崚、王志华、杨黄恬、高峰。 第九节 心脏细胞收缩/舒张功能及胞内钙离子浓度的测定,P61-69。 《心血管肾脏生理学实验技术方法及其进展》, 朱妙章主编,第四军医大学出版社。 2010.1
2. 高崚、王志华、杨黄恬。 第十节 心肌细胞模拟缺血/再灌注模型和同步收缩与钙信号的记录分析,P70-73. 《心血管肾脏生理学实验技术方法及其进展》, 朱妙章主编,第四军医大学出版社。
3. Huangtian Yang, Zhaonian Zhou, Le Chen. Effects and mechanism of hypoxia on cardiovascular function. P416-424. In Cardiovascular Physiology: Basic Science and Clinical Relevance. High Education Press, China, 2010.
4. Yang WW, Wang ZH, Zhu Y, Yang HT. Biological roles and regulatory mechanisms of transcription factor E2F6 in Control of Celluar Phyiology by E2F Transcription Factors. Edited by Dr. Kenichi Yoshida, Research Signpost. 2008
5. Huang-Tian Yang, Yan Xie, Wei-Zhong Zhu, Yi Zhu, Le Chen, Zhao-Nian Zhou. Intermittent high altitude hypoxia protects the heart against lethal Ca2+ overload injury. In Ge Ri-Li and Peter Hackett《Life On The QingHai-Tibetan Plateau》. P312-317, Peking University Medical Press, 2007
6. Huang-Tian Yang, Le Chen, Zhao-Nian Zhou. Researches of the intermittent hypoxia in prevention and treatment of ischemic heart diseases. In Weifeng Shen ed.: Frontier in Cardiology. People´s Military Medical Press, 2007.
7. Huangtian Yang, Zhaonian Zhou, Le Chen. Effects and mechanism of hypoxia on cardiovascular function. In Cardiovascular Physiology: Basic Science and Clinical Relevance. High Education Press, China, 2004.
8. 杨黄恬、张润荃、徐国彤。 健康科学中心。 《走近中国科学院》生物学分册、生物学下卷。白春礼主编。科学出版社。2003年10月
9. Anna M. Wobus, Guan, K., Huang-Tian Yang & Kenneth R. Boheler. Embryonic stem cells as a model to study cardiac, skeletal muscle, and vascular smooth muscle cell differentiation. In Turksen K ed.: Embryonic Stem Cells: Method and Protocols. Series: Methods in Molecular Biology, Vol. 185: 127-156, Humana Press Inc., Totowa, New ersey, 2002

专利
1. 一种保护心脏的物质。杨黄恬、张彩梅、高崚。申请号:201010248982.8, 申请日期:2010年8月10日, 申请人:中国科学院上海生命科学研究院
2. HSP27在制备改善缺血后心脏收缩功能方面药物的应用。 杨黄恬、陆熙园。专利号:ZL 2006 1 0030148.5, 专利申请日期:2006年8月17日, 专利权人:中国科学院上海生命科学研究院, 授权公告日:2010年12月29日
3. 一种促进胚胎干细胞向心肌细胞分化的方法。杨黄恬、王嵘。专利号:ZL 2006 1 0026575.6, 专利申请日期:2006年5月16日, 专利权人:中国科学院上海生命科学研究院, 授权公告日:2011年4月20日
4. 间歇性低氧对心肌梗塞的治疗作用。杨黄恬、周兆年、许伟青、朱仪。专利号:ZL 2005 1 0112359.9, 专利申请日期:2005年12月29日, 专利权人:中国科学院上海生命科学研究院, 授权公告日:2011年2月9日

Group Members

LMC members:
Yang Huangtian, MD, PhD, Principle Investigator
Zhang Min, MD, PhD, Associate Investigator
Liu Meilan, MD, PhD, Assistant Investigator
Jiang Yukun, BS, Research Assistant
Gao Ling, PhD, Assistant Investigator
Tang Yan, PhD, Assistant Investigator
Lu Jizhen, MS, Assistant Investigator
Liang He, PhD, Postdoctor

MS- PhD candidates of Shanghai Institutes for Biological Sciences, CAS:
Huang Jijun, PhD candidate
Wang Yijie, PhD candidate
Hong Yazhen, PhD candidate
Liu Jinlong, PhD candidate
Zhang Peng, PhD candidate
Chu Liming, PhD candidate
Tan Jiliang, PhD candidate
Gu Shanshan, PhD candidate
Li Xuxia PhD candidate
Wu Qiang, PhD candidate
Liu Qiao, MS candidate
Bai Huajun, MS candidate

MS-PhD Candidates of Shanghai Jiaotong University School of Medicine:
Zhu Wenmin, PhD candidate
Chen Zhongyan, PhD candidate
Chen Yixiong, PhD candidate
Zheng Yanjun, PhD candidate
Wang Jinxi, PhD candidate
Chen Fei, MS candidate
Wang Jinxi, PhD candidate

 
 
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