An Institute Devoted to Translational Biomedical Research
Home | Contact | Links | 简体中文版
Keywords:
  About Us Research Graduate Education Cooperation and Exchange Translational Research System Technology Platforms Faculty and Staff Join Us  
Home  »  Faculty and Staff  »  Principal Investigators
Principal Investigators
 
 

Faculty and Staff

Principal Investigators
Administration
Others
 
JING Qing
M.D., Ph.D., Professor, Principal Investigator
Laboratory of Nucleic acids & Molecular Medicine
Emaul: qjing@@sibs.ac.cn
 

Research Interests or Current Research Focus
1. Identification of tissue- and cell-specific MicroRNAs in cardiovascular systems and their physiological, pathological significance.
2. Regulation on differentiation of embryonic stem cells to cardiomyocytes, endothelial cells.
3. Mechanism of AU-rich Elements directed mRNA degradation on post-transcriptional gene regulation.
4. Lipid metabolism and molecular mechanism of atherosclerosis.

Education
1990 M.D., Second Military Medical University, Shanghai
1997 Ph.D., Second Military Medical University, Shanghai
1997-1999 Postdoctoral fellow, Shanghai Institute of Cell Biology, Chinese Academy of Sciences

Major Academic Appointments
1990-1994 Physician, Department of Cardiology, Changhai Hospital, Shanghai
1994-1997 Physician, Department of Cardiology, Changzhen Hospital, Shanghai
1997-2000 Attending Physician, Department of Cardiology, Changhai Hospital, Shanghai
2000-2004 Guest Scientist, The Scripps Research Institute, U.S.A.
2005-Present Principal Investigator, Institute of health Sciences,
Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, Shanghai

Recent Publications

  1. Tian FJ, An LN, Wang GK, Zhu JQ, Li Q, Zhang YY, Zeng A, Zou J, Zhu RF, Han XS, Shen N, Yang HT, Zhao XX, Huang S, Qin YW, Jing Q. Elevated microRNA-155 promotes foam cell formation by targeting HBP1 in atherogenesis. Cardiovasc Res. 2014;103(1):100-10. (http://cardiovascres.oxfordjournals.org/content/103/1/100.long)
    Related Editorial: Hartmann P, Schober A, Weber C. MicroRNA-155 and macrophages: a fatty liaison. Cardiovasc Res. 2014; 103(1):5-6. (http://cardiovascres.oxfordjournals.org/content/103/1/5.long)
  2. Zeng A, Li YQ, Wang C, Han XS, Li G, Wang JY, Li DS, Qin YW, Shi Y, Brewer G, Jing Q. Heterochromatin protein 1 promotes self-renewal and triggers regenerative proliferation in adult stem cells. J Cell Biol. 2013; 201(3):409-25.
  3. Zhang Z, Qin YW, Brewer G, Jing Q. MicroRNA degradation and turnover: regulating the regulators. Wiley Interdiscip Rev RNA. 2012;3(4):593-600.
  4. Zhou B, Li C, Qi W, Zhang Y, Zhang F, Wu JX, Hu YN, Wu DM, Liu Y, Yan TT, Jing Q, Liu MF, Zhai QW. Downregulation of miR-181a upregulates sirtuin-1 (SIRT1) and improves hepatic insulin sensitivity. Diabetologia. 2012;55(7):2032-43.
  5. Shao P, Liao JY, Guan DG, Yang JH, Zheng LL, Jing Q, Zhou H, Qu LH. Drastic expression change of transposon-derived piRNA-like RNAs and microRNAs in early stages of chicken embryos implies a role in gastrulation. RNA Biol. 2012 Feb 1;9(2):213-218.
  6. Shao Q, Shen LH, Hu LH, Pu J, Jing Q, He B. Atorvastatin suppresses inflammatory response induced by oxLDL through inhibition of ERK phosphorylation, IκBα degradation, and COX-2 expression in murine macrophages. J Cell Biochem. 2012;113(2):611-8.
  7. Xu XD, Song XW, Li Q, Wang GK, Jing Q*, Qin YW. Attenuation of microRNA-22 derepressed PTEN to effectively protect rat cardiomyocytes from hypertrophy. J Cell Physiol. 2012 Apr;227(4):1391-8.
  8. Li Y, Zhang Z, Liu F, Vongsangnak W, Jing Q*, Shen B*. Performance comparison and evaluation of software tools for microRNA deep-sequencing data analysis. Nucleic Acids Res. 2012 Jan 28, doi:10.1093/nar/gks043. [Epub ahead of print]
  9. Qi MY, Wang ZZ, Zhang Z, Shao Q, Zeng A, Li XQ, Li WQ, Wang C, Tian FJ, Li Q, Zou J, Qin YW, Brewer G, Huang S, Jing Q. AU-Rich Element-Dependent Translation Repression Requires the Cooperation of Tristetraprolin and RCK/P54. Mol Cell Biol. 2012 Mar;32(5):913-28.
  10. Li YQ, Zeng A, Han XS, Wang C, Li G, Zhang ZC, Wang JY, Qin YW, Jing Q. Argonaute-2 regulates the proliferation of adult stem cells in planarian. Cell Res. 2011;21(12):1750-4.
  11. Zou J, Li WQ, Li Q, Li XQ, Zhang JT, Liu GQ, Chen J, Qiu XX, Tian FJ, Wang ZZ, Zhu N, Qin YW, Shen B, Liu TX*, Jing Q*. Two Functional MicroRNA-126s Repress a Novel Target Gene P21-Activated Kinase1 to Regulate Vascular Integrity in Zebrafish. Circ Res. 2011 Jan 21;108(2):201-9.
  12. Zhang Z, Zou J, Wang GK, Zhang JT, Huang S, Qin YW, Jing Q*. Uracils at nucleotide position 9-11 are required for the rapid turnover of miR-29 family. Nucleic Acids Res. 2011; 39(10): 4387-4395.
  13. Li Q, Song XW, Zou J, Wang GK, Kremneva E, Li XQ, Zhu N, Sun T, Lappalainen P, Yuan WJ, Qin YW, Jing Q*. Attenuation of microRNA-1 derepresses the cytoskeleton regulatory protein twinfilin-1 to provoke cardiac hypertrophy. J Cell Sci. 2010 Jul 15;123(14):2444-52. PubMed PMID: 20571053.
  14. Wang GK, Zhu JQ, Zhang JT, Li Q, Li Y, He J, Qin YW, Jing Q*. Circulating microRNA: a novel potential biomarker for early diagnosis of acute myocardial infarction in humans. Eur Heart J. 2010 Mar;31(6):659-66. PubMed PMID: 20159880.
  15. Song XW, Li Q, Lin L, Li DF, Wang GK, Ren AJ, Qin YW, Yuan WJ, Jing Q*. MicroRNAs are dynamically regulated in hypertrophic hearts, and miR-199a is essential for the maintenance of cell size in cardiomyocytes. J Cell Physiol. 2010 May 10. 225:437-443. PubMed PMID: 20458739.
  16. Shao Q, Shen LH, Hu LH, Pu J, Qi MY, Li WQ, Tian FJ, Jing Q*, He B*. Nuclear receptor Nur77 suppresses inflammatory response dependent on COX-2 in macrophages induced by oxLDL. J Mol Cell Cardiol. 2010 Aug;49(2):304-11. PubMed PMID: 20381497.
  17. Liu G, Ding M, Chen J, Huang J, Wang H, Jing Q*, Shen B*. Computational analysis of microRNA function in heart development. Acta Biochimica et Biophysica Sinica. 2010 Sep;42(9):662-70.
  18. Kong X, Du Y, Wang G, Gao J, Gong Y, Li L, Zhang Z, Zhu J, Jing Q, Qin Y, Li Z. Detection of Differentially Expressed microRNAs in Serum of Pancreatic Ductal Adenocarcinoma Patients: miR-196a Could Be a Potential Marker for Poor Prognosis. Dig Dis Sci. 2011 Feb;56(2):602-9. PMID: 20614181.
  19. Tang B, Wu X, Tan G, Chen SS, Jing Q, Shen B. Computational inference and analysis of genetic regulatory networks via a supervised combinatorial-optimization pattern. BMC Systems Biology. 2010 Sep 13;4 Suppl 2:S3.
  20. Tang B, He L, Jing Q, Shen B. Model-based Identification & Adaptive Control of the Core Module in a Typical Cell Cycle Pathway via Network and System Control Theories. Advances in Complex Systems, 2009,12(1),21-43.
  21. Fu YF, Du TT, Dong M, Zhu KY, Jing CB, Zhang Y, Wang L, Fan HB, Chen Y, Jin Y, Yue GP, Chen SJ, Chen Z, Huang QH, Jing Q, Deng M, Liu TX. Mir-144 selectively regulates embryonic alpha-hemoglobin synthesis during primitive erythropoiesis. Blood. 2009 Feb 5;113(6):1340-9. PubMed PMID: 18941117.
  22. Otsuka M, Jing Q, Georgel P, New L, Chen J, Mols J, Kang YJ, Jiang Z, Du X, Cook R, Das SC, Pattnaik AK, Beutler B, Han J. Hypersusceptibility to vesicular stomatitis virus infection in Dicer1-deficient mice is due to impaired miR24 and miR93 expression. Immunity. 2007 Jul;27(1):123-34. PubMed PMID: 17613256.
  23. Shen FM, Zhang SH, Xie HH, Jing Q, Wang DS, Su DF. Early structural changes of aortic wall in sinoaortic-denervated rats. Clin Exp Pharmacol Physiol. 2006 Apr;33(4):358-63. PubMed PMID: 16620301.
  24. Zarubin T, Jing Q, New L, Han J. Identification of eight genes that are potentially involved in tamoxifen sensitivity in breast cancer cells. Cell Res. 2005 Jun;15(6):439-46. PubMed PMID: 15987602.
  25. Jing Q, Huang S, Guth S, Zarubin T, Motoyama A, Chen J, Di Padova F, Lin SC, Gram H, Han J. Involvement of microRNA in AU-rich element-mediated mRNA instability. Cell. 2005 Mar 11;120(5):623-34.
  26. Kim SO*, Jing Q*, Hoebe K, Beutler B, Duesbery NS, Han J. Sensitizing anthrax lethal toxin-resistant macrophages to lethal toxin-induced killing by tumor necrosis factor-alpha. (*Both authors contributed equally to this work.) J Biol Chem. 2003 Feb 28; 278(9):7413-21.
  27. Ge B, Xiong X, Jing Q, Mosley JL, Filose A, Bian D, Huang S, Han J. TAB1beta (transforming growth factor-beta-activated protein kinase 1-binding protein 1beta ), a novel splicing variant of TAB1 that interacts with p38alpha but not TAK1. J Biol Chem. 2003 Jan 24; 278(4):2286-93.
  28. Lei ZB, Zhang Z, Jing Q, Qin YW, Pei G, Cao BZ, Li XY. OxLDL upregulates CXCR2 expression in monocytes via scavenger receptors and activation of p38 mitogen-activated protein kinase. Cardiovasc Res. 2002 Feb 1; 53(2):524-32.
  29. Qiu J, Wang P, Jing Q, Zhang W, Li X, Zhong Y, Sun G, Pei G, Chen Y. Rapid activation of ERK1/2 mitogen-activated protein kinase by corticosterone in PC12 cells. Biochem Biophys Res Commun. 2001 Oct 5; 287(4):1017-24.
  30. Jing Q, Xin SM, Zhang WB, Wang P, Qin YW, Pei G. Lysophosphatidylcholine activates p38 and p42/44 mitogen-activated protein kinases in monocytic THP-1 cells, but only p38 activation is involved in its stimulated chemotaxis. Circ Res. 2000 Jul 7;87(1):52-9.
  31. Zhou TH, Ling K, Guo J, Zhou H, Wu YL, Jing Q, Ma L, Pei G. Identification of a human brain-specific isoform of mammalian STE20-like kinase 3 that is regulated by cAMP-dependent protein kinase. J Biol Chem. 2000 Jan 28;275(4):2513-9.
  32. Jing Q, Xin SM, Cheng ZJ, Zhang WB, Zhang R, Qin YW, Pei G. Activation of p38 mitogen-activated protein kinase by oxidized LDL in vascular smooth muscle cells: mediation via pertussis toxin-sensitive G proteins and association with oxidized LDL-induced cytotoxicity. Circ Res. 1999 Apr 16; 84(7):831-9.
  33. Zhang R, Wang GL, Zhang PL, Xiong Y, Zhang WB, Wang XP, Yin DL, Jing Q*. Suppression of angiotensin II stimulated responses in aortic vascular smooth muscle cells of experimental cirrhotic rats.(* corresponding author) Cell Res. 1999 Jun;9(2):155-61.

Group Members

 
 
Copyright 2002-2016 The Institute of Health Sciences, SIBS, CAS / SJTUSM All Rights Reserved
225 South Chongqing Road, Shanghai, 200025 P.R. China Tel: 86-21-63847798 / 54923254 Fax: 86-21-63852579
Shanghai ICP #05033115