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Principal Investigators
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ZHANG Xiaoren
Ph.D., Principal Investigator
Laboratory of Immune Regulation and Tolerance
Email: xrzhang@@sibs.ac.cn
 

Research Interests or Current Research Focus
We are interested in the roles of NF-κB, STAT3 and their regulatory proteins in the establishment of immunological tolerance, the development and function of immune cells, and inflammation-associated tumor development and progression.

Education
1992-1995: Shandong Academy of Medical Sciences, Master Degree
?1995-199: Shanghai Second Medical University, Shanghai Institute of Immunology, Ph.D.

Major Academic Appointments
1998-1999: Shanghai Second Medical University, Shanghai Institute of Immunology, Instructor
1999-2001: Holland Laboratory, American Red Cross, Postdoctoral Fellow
2001-2004: NIH/NIAID/LIR, Visiting Fellow
2004-2009: NIH/NIAID/LIR, Postdoctoral Fellow, Research Fellow
2008-present: Institute of Health Sciences, SIBS, CAS/SJTUSM, China,Principal Investigator

Recent Publications

  1. Ge QL, Liu SH, Ai ZH, Tao MF, Ma L, Wen SY, Dai M, Liu F, Liu HS, Jiang RZ, Xue ZW, Jiang YH, Sun XH, Hu YM, Zhao YX, Chen X, Tao Y, Zhu XL, Ding WJ, Yang BQ, Liu DD, Zhang XR, Teng YC. RelB/NF-κB links cell cycle transition and apoptosis to endometrioid adenocarcinoma tumorigenesis. Cell Death Dis. 2016 Oct 6;7(10):e2402. doi: 10.1038/cddis.2016.309.(共同通讯作者)
  2. Sun X, Liu S, Chen P, Fu D, Hou Y, Hu J, Liu Z, Jiang Y, Cao X, Cheng C, Chen X, Tao Y, Li C, Hu Y, Liu Z, Zhan Y, Mao J, Wang Q, Ma Y, Cong X, Sun R, Shi Y, Wang M, Zhang X. miR-449a inhibits colorectal cancer progression by targeting SATB2. Oncotarget. 2016 Jul 28. doi: 10.18632/oncotarget.10900. [Epub ahead of print] (共同通讯作者)
  3. Zhan Y, Wei Y, Chen P, Zhang H, Liu D, Zhang J, Liu R, Chen R, Zhang J, Mo W, Zhang X. Expression, purification and biological characterization of the extracellular domain of CD40 from Pichia pastoris. BMC Biotechnol. 2016 Jan 25;16(1):8. doi: 10.1186/s12896-016-0237-1.(共同通讯作者)
  4. Liu Z, Cao W, Xu L, Chen X, Zhan Y, Yang Q, Liu S, Chen P, Jiang Y, Sun X, Tao Y, Hu Y, Li C, Wang Q, Wang Y, Chen CD, Shi Y, Zhang X. The histone H3 lysine-27 demethylase Jmjd3 plays a critical role in specific regulation of Th17 cell differentiation. J Mol Cell Biol. 2015 Dec;7(6):505-16. (共同通讯作者)
  5. Zhang R, Jin S, Rao W, Song F, Yin Q, Wang Y, Wang L, Xi Y, Zhang X, Wang M, Ge H. OVA12, a novel tumor antigen, promotes cancer cell growth and inhibits 5-fluorouracil-induced apoptosis. Cancer Lett. 2015 Feb 1;357(1):141-51.
  6. Liu S, Sun X, Wang M, Hou Y, Zhan Y, Jiang Y, Liu Z, Cao X, Chen P, Liu Z, Chen X, Tao Y, Xu C, Mao J, Cheng C, Li C, Hu Y, Wang L, Chin YE, Shi Y, Siebenlist U, Zhang X. A microRNA 221- and 222-Mediated Feedback Loop, via PDLIM2, Maintains Constitutive Activation of NFκB and STAT3 in Colorectal Cancer Cells. Gastroenterology. 2014 Jun 12. pii: S0016-5085(14)00744-6. doi: 10.1053/j.gastro.2014.06.006. [Epub ahead of print] (通讯作者)
  7. Chen Q, Shou P, Zhang L, Xu C, Zheng C, Han Y, Li W, Huang Y, Zhang X, Shao C, Roberts AI, Rabson AB, Ren G, Zhang Y, Wang Y, Denhardt DT, Shi Y. An Osteopontin-Integrin interaction plays a critical role in directing adipogenesis and osteogenesis by mesenchymal stem cells. Stem Cells. 2014 Feb;32(2):327-37.
  8. Chen P, Zhang J, Zhan Y, Su J, Du Y, Xu G, Shi Y, Siebenlist U, Zhang X. Established Thymic Epithelial Cell Progenitor/ Stem Cell Lines Differentiate into Mature Thymic Epithelial Cells and Support T Cell Development. PloS One. 2013 Sep 23;8(9):e75222. doi: 10.1371/journal.pone.0075222. (通讯作者)
  9. Liu Z, Jiang Y, Hou Y, Hu Y, Cao X, Tao Y, Xu C, Liu S, Wang S, Wang L, Shi Y, Siebenlist U, Zhang X. The IκB family member Bcl-3 stabilizes c-Myc in colorectal cancer. J Mol Cell Biol. 2013 Aug;5(4):280-2. (通讯作者)
  10. Zhang X, Paun A, Claudio E, Wang H, Siebenlist U. The Tumor Promoter and NF-κB Modulator Bcl-3 Regulates Splenic B Cell Development. J Immunol. 2013 Nov 15. 191(12):5984-92. (共同通讯作者)
  11. Liu B, Liu YF, Du YR, Mardaryev AN, Yang W, Chen H, Xu ZM, Xu CQ, Zhang XR, Botchkarev VA, Zhang Y, Xu GL. Cbx4 regulates the proliferation of thymic epithelial cells and thymus function. Development. 2013 Feb;140(4):780-8.
  12. Wang S, Liu Z, Wang L, Zhang X. NF-kappaB signaling pathway, inflammation and colorectal cancer. Cell Mol Immunol. 2009 Oct; 6(5):327-34. (通讯作者)
  13. Zhang, X., Wang, H., Claudio, E., Brown, K., and Siebenlist, U. (2007). A role for the IkappaB family member Bcl-3 in the control of central immunologic tolerance. Immunity, 27, 438-452.
  14. Zhang XR, Zhang LY, Devadas S, Li L, Keegan AD, Shi YF. Reciprocal expression of TRAIL and CD95L in Th1 and Th2 cells: role of apoptosis in T helper subset differentiation. Cell Death and Differentiation, 2003, 10:203.
  15. Roberts AI, Devadas S, Zhang X, Zhang L, Keegan A, Greeneltch K, Solomon J, Wei L, Das J, Sun E, Liu C, Yuan Z, Zhou JN, Shi Y. The role of activation-induced cell death in the differentiation of T-helper-cell subsets. Immunol Res., 2003, 28:285.
  16. Wang R, Zhang L, Zhang X, Moreno J, Celluzzi C, Tondravi M, Shi Y. Regulation of activation- induced receptor activator of NF-κB ligand (RANKL) expression in T cells. Eur J Immunol. 2002 Apr;32(4):1090-8.
  17. Wang R, Zhang L, Zhang X, Moreno J, Luo X, Tondravi M, Shi Y. Differential regulation of the expression of CD95 ligand, receptor activator of nuclear factor-κB ligand (RANKL), TNF-related apoptosis-inducing ligand (TRAIL), and TNF-a during T cell activation. J Immunol., 2001, 166:1983-1990.

Invited reviews, comments and book chapters
Patent Licensed
1,抑制肿瘤转移的方法和试剂专利申请号:201210380158.7(第一申请人)
PatentsFiled
1,一种CD40胞外区的表达纯化及其应用专利申请号:201410680486.8(第一申请人)
2,预防和治疗结直肠癌的方法和试剂专利申请号:201210320127.2(第一申请人)
3,利用microRNA海绵技术预防和治疗肿瘤的方法专利申请号:201210295556.9(第一申请人)

Group Members

 
 
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