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Principal Investigators

Faculty and Staff

Principal Investigators
HU Guohong
Ph.D., Principal Investigator
Laboratory of Tumor Metastasis

Research Interests or Current Research Focus
1. Establishment of xenograft animal models of cancer metastasis;
2. Identification of biomarkers and functional genes in metastasis;
3. Epigenetic regulation of metastasis genes;
4. Molecular network in breast cancer metastasis.

Major Research Achievement
1. Development of microarray systems utilizing the multiplex PCR technology with the superior sensitivity to analyze limited clinical samples or even single cells.
2. Development of a bioinformatic tool for cytogenetic analysis with gene expression profiling data.
3. Discovery of a genomic gain at chromosome 8q22 in metastatic tumors of breast and prostate cancers.
4. Discovery of a novel metastasis gene Metadherin with dual-functionality to promote tumor cells metastatic seeding and chemoresistance.

1996-2000 Tsinghua University, Department of Biological Sciences and Technology, B.S.
2000-2002 Rutgers University, U.S., Biology Department, M.S.
2000-2005 Rutgers University-UMDNJ Joint Program, Department of Molecular Genetics, Microbiology and Immunology, Ph.D.

Major Academic Appointments
2005 Princeton University, Department of Molecular Biology, Postdoctoral Research Associate
2009 Princeton University, Department of Molecular Biology, Associate Research Scholar
2009 Principal Investigator, Institute of Health Sciences, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences

Recent Publications

  1. Zhuang X, Zhang H, Li X, Li X, Cong M, Peng F, Yu J, Zhang X, Yang Q*, Hu G*. Differential effects on lung and bone metastasis of breast cancer by Wnt signalling inhibitor DKK1. Nat Cell Biol, in press.
  2. Hu J#, Li G#, Zhang P, Zhuang X, Hu G. A CD44v+ subpopulation of breast cancer stem-like cells with enhanced lung metastasis capacity. Cell Death Dis, 2017;8(3):e2679.
  3. Li N, Xue W, Yuan H, Dong B, Ding Y, Liu Y, Jiang M, Kan S, Sun T, Ren J, Pan Q, Li X, Zhang P, Hu G, Wang Y, Wang X, Li Q, Qin J. AKT-mediated Stabilization of WHSC1 Promotes Prostate Cancer Metastasis. J Clin Invest, 2017;127(4):1284-1302.
  4. Panayotopoulou E, Börries M, Busch H, Hu G, Lev S. Targeting of apoptotic pathways by SMAC or BH3 mimetics distinctly sensitizes paclitaxel-resistant triple negative breast cancer cells. Oncotarget, 2017;8(28):45088-45104.
  5. Li G, Li M, Hu J, Lei R, Xiong H, Ji H, Yin H, Wei Q, Hu G. The microRNA-182-PDK4 axis regulates lung tumorigenesis by modulating pyruvate dehydrogenase and lipogenesis. Oncogene, 2017;36(7):989-998.
  6. Yu J#, Lei R#, Zhuang X, Li X, Li G, Lev S, Segura MF, Zhang X, Hu G. MicroRNA-182 targets SMAD7 to potentiate TGFβ-induced epithelial-mesenchymal transition and metastasis of cancer cells. Nat Commun, 2016;7:13884.
  7. Chen X, Cao X, Sun X, Lei, Chen P, Zhao Y, Jiang Y, Yin J, Chen R, Ye D, Wang Q, Liu Z, Liu S, Cheng C, Mao J, Hou Y, Wang M, Siebenlist Ut, Chin E, Wang Y, Cao L, Hu G*, Zhang X*. Bcl-3 regulates TGFβ signaling by stabilizing Smad3 during breast cancer pulmonary metastasis. Cell Death Dis, 2016;7(12):e2508.
  8. Yu PF, Huang Y, Xu CL, Lin LY, Han YY, Sun WH, Hu G, Rabson AB, Wang Y, Shi Y. Downregulation of CXCL12 in mesenchymal stromal cells by TGFβ promotes breast cancer metastasis. Oncogene, 2016;doi: 10.1038/onc.2016.252.
  9. Liang Y, Hu J, Li J, Liu Y, Yu J, Zhuang X, Mu L, Kong X, Hong D, Yang Q, Hu G. Epigenetic activation of TWIST1 by MTDH promotes cancer stem-like Cell traits in breast cancer. Cancer Res, 2015;75:3672.
  10. Chen F, Zhuang X, Lin L, Yu P, Wang Y, Shi Y, Hu G and Sun Y. New horizons in tumor microenvironment biology: challenges and opportunities. BMC Medicine, 2015;13:45.
  11. Wan L, Hu G, Wei Y, Yuan M, Bronson RT, Yang Q, Siddiqui J, Pienta KJ, Kang Y. Genetic ablation of metadherin inhibits autochthonous prostate cancer progression and metastasis. Cancer Res, 2014;74(18):5336-47.
  12. Lin B#, Wang Y#, Wang Z, Tan H, Kong X, Shu Y, Zhang Y, Huang Y, Zhu Y, Xu H, Wang Z, Wang P, Ning G, Kong X*, Hu G*, and Hu L*. Uncovering the rare variants of DLC1 isoform 1 and their functional effects in a Chinese sporadic congenital heart disease cohort. PLoS One, 2014;28;9(2):e90215. (*Corresponding)
  13. Wang Y, Lei R, Zhuang X, Zhang N, Pan H, Li G, Hu J, Pan X, Tao Q, Fu D, Xiao J, Chin E, Kang Y, Yang Q*, Hu G*. DLC1-dependent parathyroid hormone-like hormone inhibition suppresses breast cancer bone metastasis. J Clin Invest, 2014;124(4):1646-59.
  14. Zhang N, Wang X, Huo Q, Sun M, Cai C, Liu Z, Hu G, Yang Q. MicroRNA-30a suppresses breast tumor growth and metastasis by targeting metadherin. Oncogene, 2014;33(24):3119-28.
  15. Lei R#,Tang J#, Zhuang X, Deng R, Li G, Yu J, Liang Y, Xiao J, Wang H-Y, Yang Q, Hu G. Suppression of MIM by microRNA-182 activates RhoA and promotes breast cancer metastasis. Oncogene, 2013;33(10):1287-96.
  16. Zhang N, Wang X, Huo Q, Li X, Wang H-Y, Schneider P, Hu G*, Yang Q*. The oncogene metadherin modulates the apoptotic pathway based on the tumor necrosis factor superfamily member TRAIL in breast cancer. J Biol Chem, 2013;288(13):9396-407. (*Corresponding)
  17. Liang Y, Wu H, Lei R, Chong RA, Wei Y, Lu X, Tagkopoulos I, Kung S-Y, Yang Q, Hu G*, Kang Y*. Transcriptional Network Analysis Identifies BACH1 as A Master Regulator of Breast Cancer Bone Metastasis. J Biol Chem, 2012 Sep 28;287(40):33533-44. (*Corresponding)
  18. Jin L, Zhang Y, Li H, Fu D, Yao X, Xu L, Hu G. Differential Secretome Analysis Reveals CST6 as a Suppressor of Breast Cancer Bone Metastasis. Cell Res, 2012 Sep;22(9):1356-73.
  19. Yu X, Wang F, Liu H, Adams G, Aikhionbare F, Liu D, Cao X, Fan L, Hu G, Chen Y, Frost A, Partridge E, Ding X, Yao X. ACAP4 cooperates with GRB2 to orchestrate EGF-stimulated integrin beta1 recycling in cell migration. J Biol Chem, 2011;286(51):43735-47.
  20. Korpal M, Ell B, Buffa F, Khan Z, Blanco M, Hua Y, Wei Y, Hu G, Garcia B, Ragoussis J, Singh M, Harris A, and Kang Y. Direct targeting of Sec23a by miR-200s influences cancer cell secretome and promotes metastatic colonization. Nature Medicine, 2011;17(9):1101-8.
  21. Shan J#, Budijono S#, Hu G#, Yao N, Kang Y, Ju Y*, and Prud’homme R*. PEGylated composite nanoparticles containing upconverting phosphors and meso-tetraphenyl porphine (TPP) for photodynamic therapy. Advanced Functional Materials, 2011;21(13):2488-95. (# equal contributors)
  22. Lu X, Yan C, Yuan M, Wei Y, Hu G, and Kang Y. In Vivo Dynamics and Distinct Functions of Hypoxia in Primary Tumor Growth and Organotropic Metastasis of Breast Cancer. Cancer Research. 2010;70(10):3905-14.
  23. Hu G, Wei Y, and Kang Y. The multifaceted role of MTDH/AEG-1 in cancer progression. Clinical Cancer Research, 2009;15(18):5615-20.
  24. Hu G, Kang Y., and Wang X-F. From breast to the brain: unraveling the puzzle of metastasis organotropism. J Mol Cell Biol, 2009;1(1):3-5.
  25. Hu G#, Chong R#, Yang Q, Wei Y, Li F, Blanco A, Reiss M, Au J-S, Haffty B, and Kang Y. MTDH activation by 8q22 genomic gain promotes chemoresistance and metastasis of poor-prognosis breast cancer. Cancer Cell, 2009; 15(1):9-20. (Cover article. Rated as “Exceptional” by Faculty 1000 of Biology)
  26. Lu X, Wang Q, Hu G, Poznak CV, Fleisher M, Reiss M, Massagué J and Kang Y. ADAMTS1 and MMP1 proteolytically engage EGF-like growth factors in an osteolytic paracrine signaling cascade to promote breast cancer bone metastasis. Genes & Development. 2009; 23(16):1882-94.
  27. Hu G, Yang Q, Yue G, Azaro MA, Wang H-Y, Cui X, and Li H. A highly sensitive and specific system for large-scale gene expression profiling. BMC Genomics, 2008; 9:9. (* equal contributors) (Rated as “Highly Accessed” article by BMC).
  28. Korpal M, Lee ES, Hu G, and Kang Y. The miR-200 family inhibits epithelial-mesenchymal transition and cancer cell migration by direct targeting of E-cadherin transcriptional repressors ZEB1 and ZEB2. J Biol Chem., 2008;283:14910-4.
  29. Hu G, Wang, H-Y, Frikker DM, Azaro MA, Luo M, Tereshchenko IV, Cui X, Yang J-M, Gao R, Shen L, and Li H. AccuTyping: New algorithms for automated analysis of data from high-throughput genotyping with oligonucleotide microarrays. Nucleic Acids Research, 2006; 34(17):e116.
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